INT253122

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.81
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Ins1, Akt1) cytoplasm (Ins1, Akt1) transport (Akt1)
aging (Akt1) enzyme binding (Akt1) cytosol (Akt1)
Anatomy Link Frequency
skeletal muscle 1
Ins1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 19 89.80 High High
Pain 4 64.84 Quite High
Inflammation 10 62.96 Quite High
tolerance 18 36.28 Quite Low
agonist 10 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 90 99.14 Very High Very High Very High
Shock 184 88.16 High High
Diabetes Mellitus 28 86.96 High High
Hyperglycemia 15 85.28 High High
Wound Healing 2 81.32 Quite High
Targeted Disruption 7 76.88 Quite High
Cancer 5 68.92 Quite High
Pain 4 64.84 Quite High
Fracture Healing 2 63.88 Quite High
INFLAMMATION 10 62.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because insulin resistance is characterized by a marked reduction in insulin-stimulated PI3K-mediated activation of Akt, we asked whether MES could increase Akt phosphorylation and ameliorate insulin resistance.
insulin Positive_regulation (activation) of Akt associated with insulin resistance
1) Confidence 0.15 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2603588 Disease Relevance 0.88 Pain Relevance 0
There is consensus that a marked reduction in insulin-stimulated PI3K-mediated activation of Akt results in decreased insulin sensitivity in vivo [14], [15], [16], [17].
insulin Positive_regulation (activation) of Akt
2) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.85 Pain Relevance 0.10
This increase is a consequence of the activation of AMPK and AKT by IL-6 and insulin, respectively, and is additive to AS160 phosphorylation, as observed in C2C12 cells and in skeletal muscle, in agreement with other reports (3,12,40).
insulin Positive_regulation (activation) of AKT in skeletal muscle
3) Confidence 0.13 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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