INT253127

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.31
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn1) cytosol (Ptpn1) extracellular space (Il6)
extracellular region (Il6) endoplasmic reticulum (Ptpn1)
Il6 (Mus musculus)
Ptpn1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 51 84.44 Quite High
agonist 30 55.68 Quite High
tolerance 18 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 120 99.40 Very High Very High Very High
Obesity 60 71.24 Quite High
Diabetes Mellitus 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 9 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Hyperinsulinism 6 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We did not detect changes in ptp1b expression by IL-6 treatment at 3 or 6 h (data not shown), but at 24 h, a significant increase on ptp1b mRNA accumulation and activity was observed (Fig. 4D and E).
IL-6 Neg (not) Regulation (changes) of Gene_expression (expression) of ptp1b
1) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.43 Pain Relevance 0.07
insulin resistance (6,7), we determined whether IL-6 treatment was modulating ptp1b expression.
IL-6 Spec (whether) Regulation (modulating) of Gene_expression (expression) of ptp1b associated with insulin resistance
2) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.42 Pain Relevance 0.07
However, IL-6 effects on PTP1B expression and activity were completely prevented by treatment with GW3965 or SP600125.


IL-6 Regulation (effects) of Gene_expression (expression) of PTP1B
3) Confidence 0.24 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.45 Pain Relevance 0.04

General Comments

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