INT253129

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.66
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Ins1, Akt1) cytoplasm (Ins1, Akt1) transport (Akt1)
aging (Akt1) enzyme binding (Akt1) cytosol (Akt1)
Anatomy Link Frequency
muscle 2
Ins1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 30 92.56 High High
tolerance 6 85.44 High High
Inflammation 42 62.08 Quite High
agonist 10 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 57 96.80 Very High Very High Very High
Insulin Resistance 79 90.96 High High
Impaired Glucose Tolerance 3 85.44 High High
Hyperglycemia 3 71.16 Quite High
Obesity 84 67.84 Quite High
Body Weight 4 65.96 Quite High
Peripheral Arterial Disease 1 64.88 Quite High
Hypertrophy 17 62.72 Quite High
INFLAMMATION 46 62.08 Quite High
Hyperinsulinism 6 56.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the absolute level of insulin-stimulated Akt phosphorylation and the insulin-stimulated fold change in Akt phosphorylation were both significantly greater, two- and three-fold, respectively, in 12/15LO KO mice compared to WT mice.
insulin Regulation (change) of Phosphorylation (phosphorylation) of Akt associated with targeted disruption
1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.18 Pain Relevance 0.09
At the short term (3 h), IL-6 activates AMPK without affecting AKT phosphorylation by insulin.
insulin Neg (without) Regulation (affecting) of Phosphorylation (phosphorylation) of AKT
2) Confidence 0.05 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.25 Pain Relevance 0.09
In the SOL muscle, there was no effect of PTEN ablation on insulin stimulated PKB Thr308 phosphorylation (Figure S2).
insulin Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of PKB in muscle
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.24 Pain Relevance 0

General Comments

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