INT253132

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn1) cytosol (Ptpn1) extracellular space (Il6)
extracellular region (Il6) endoplasmic reticulum (Ptpn1)
Il6 (Mus musculus)
Ptpn1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 17 65.96 Quite High
agonist 10 37.20 Quite Low
tolerance 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 40 98.56 Very High Very High Very High
Obesity 20 52.76 Quite High
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Hyperinsulinism 2 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because IL-6 upregulated PTP1B expression, we decided to explore whether the lack of PTP1B might confer protection against IL-6–induced insulin resistance (Fig. 5A).
IL-6 Positive_regulation (upregulated) of Gene_expression (expression) of PTP1B associated with insulin resistance
1) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

This test has worked.

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