INT253137

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.11
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn1) cytosol (Ptpn1) extracellular space (Ins1)
extracellular region (Ins1) endoplasmic reticulum (Ptpn1) carbohydrate metabolic process (Ins1)
Anatomy Link Frequency
muscle 2
adipose tissue 2
Ptpn1 (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 40 96.68 Very High Very High Very High
Inflammation 16 93.48 High High
cytokine 68 55.28 Quite High
tolerance 24 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 160 98.44 Very High Very High Very High
Obesity 80 98.28 Very High Very High Very High
Diabetes Mellitus 24 97.16 Very High Very High Very High
INFLAMMATION 16 93.48 High High
Targeted Disruption 12 90.08 High High
Hyperinsulinism 8 70.40 Quite High
Impaired Glucose Tolerance 12 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein-tyrosine phosphatase 1B (PTP1B) acts as a physiological negative regulator of insulin, which increases expression in muscle and adipose tissue of obese and diabetic humans and rodents (27,28).
Protein-tyrosine phosphatase 1B Negative_regulation (regulator) of insulin in adipose tissue associated with diabetes mellitus and obesity
1) Confidence 0.19 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 1.03 Pain Relevance 0.16
Protein-tyrosine phosphatase 1B (PTP1B) acts as a physiological negative regulator of insulin, which increases expression in muscle and adipose tissue of obese and diabetic humans and rodents (27,28).
PTP1B Negative_regulation (regulator) of insulin in adipose tissue associated with diabetes mellitus and obesity
2) Confidence 0.19 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 1.02 Pain Relevance 0.16
Protein-tyrosine phosphatase 1B (PTP1B) acts as a physiological negative regulator of insulin, which increases expression in muscle and adipose tissue of obese and diabetic humans and rodents (27,28).
PTP1B Negative_regulation (regulator) of insulin in muscle associated with diabetes mellitus and obesity
3) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 1.02 Pain Relevance 0.16
Protein-tyrosine phosphatase 1B (PTP1B) acts as a physiological negative regulator of insulin, which increases expression in muscle and adipose tissue of obese and diabetic humans and rodents (27,28).
Protein-tyrosine phosphatase 1B Negative_regulation (regulator) of insulin in muscle associated with diabetes mellitus and obesity
4) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 1.03 Pain Relevance 0.16

General Comments

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