INT253147

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn1) cytosol (Ptpn1) endoplasmic reticulum (Ptpn1)
nucleus (Nr1h2) DNA binding (Nr1h2) cytoplasm (Nr1h2)
Anatomy Link Frequency
macrophages 3
Nr1h2 (Mus musculus)
Ptpn1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 17 100.00 Very High Very High Very High
metalloproteinase 1 100.00 Very High Very High Very High
agonist 10 91.92 High High
Inflammation 4 89.84 High High
tolerance 6 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 20 93.52 High High
INFLAMMATION 4 89.84 High High
Insulin Resistance 40 75.84 Quite High
Hyperinsulinism 2 17.48 Low Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of this inhibitory action is unknown, and thus far no LXR response elements have been identified on the ptp1b promoter, although the expression of other genes such as matrix metalloproteinase-9, induced by cytokines, was repressed by LXR activation in macrophages (50).
Positive_regulation (activation) of LXR in macrophages Negative_regulation (repressed) of Positive_regulation (induced) of ptp1b in macrophages associated with metalloproteinase and cytokine
1) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.61 Pain Relevance 0.33

General Comments

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