INT253177

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.63
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
lower jaw 2
Shh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 3 95.04 Very High Very High Very High
cytokine 10 93.76 High High
Kinase C 2 58.64 Quite High
Inflammation 5 46.56 Quite Low
Neuronal nitric oxide synthase 3 36.56 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 3 95.04 Very High Very High Very High
Diabetes Mellitus 50 93.44 High High
Gestational Diabetes 9 92.60 High High
Apoptosis 13 50.00 Quite Low
INFLAMMATION 8 46.56 Quite Low
Congenital Anomalies 8 26.88 Quite Low
Myocardial Infarction 18 17.76 Low Low
Fetal Diseases 2 8.88 Low Low
Infarction 12 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the absence of a significant difference in Shh mRNA levels between the MDn and MDm embryos, the decreased Shh expression in the MD offspring is of particular interest in relation to the findings of embryonic craniofacial (56) and aortic (57) anomalies resulting from direct inhibition of Shh, as well as the findings of an early role for Shh in securing the neural crest cell survival in the early development of the lower jaw (58).
Negative_regulation (decreased) of Gene_expression (expression) of Shh in lower jaw
1) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.54 Pain Relevance 0.03
Enhanced angiogenesis may be attributed to the multiple effects of localized Shh transgene expression.
Negative_regulation (localized) of Gene_expression (expression) of Shh transgene
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.10 Pain Relevance 0.13
During Western blot studies, subsequent Shh transfection of the respective siRNA transfected cells showed that PI3K/Akt abrogation failed to block Shh induced iNOS expression (Figure 3D; lane-3).
Negative_regulation (block) of Gene_expression (expression) of Shh
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
On the contrary, treatment of MSCs with 2.5 µM chel or 1 µM cyclopamine prior to Shh transfection significantly abolished iNOS expression in ShhMSCs (Figure 3D).
Negative_regulation (abolished) of Gene_expression (expression) of ShhMSCs
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox