INT253183

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.13
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
embryos 2
myocardium 1
lower jaw 1
osteoblast 1
Shh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 6 64.84 Quite High
cytokine 15 64.48 Quite High
Central nervous system 4 63.96 Quite High
metalloproteinase 6 33.76 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 150 99.82 Very High Very High Very High
Hypertrophy 4 99.54 Very High Very High Very High
Gestational Diabetes 27 99.40 Very High Very High Very High
Osteoporosis 14 98.26 Very High Very High Very High
Myocardial Infarction 24 94.56 High High
Stress 20 85.68 High High
Increased Venous Pressure Under Development 4 78.20 Quite High
Congenital Anomalies 42 67.00 Quite High
Apoptosis 37 50.00 Quite Low
Fetal Diseases 6 15.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas the Ret gene was unaltered by maternal diabetes, we found a diabetes-induced decrease in the Shh mRNA levels in the MD embryos.
Negative_regulation (decrease) of Shh in embryos associated with diabetes mellitus and gestational diabetes
1) Confidence 0.55 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.50 Pain Relevance 0.03
In our present study, treatment of ShhMSCs with both the PKC inhibitor chel and Shh inhibitor cyclopamine abolished PKM fragment which indicated that PKM was downstream of Shh and that PKC was essential for its upregulation.
Negative_regulation (inhibitor) of Shh
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.06 Pain Relevance 0
Significant upregulation of netrin-1 and iNOS was observed in ShhMSCs in PI3K independent but PKC dependent manner.
Negative_regulation (observed) of ShhMSCs
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797399 Disease Relevance 0.09 Pain Relevance 0
Shh was decreased, Ret was unaltered, and Bmp-4 mRNA levels were increased in MD embryos compared with N embryos (Fig. 4).
Negative_regulation (decreased) of Shh in embryos
4) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.36 Pain Relevance 0
Despite the absence of a significant difference in Shh mRNA levels between the MDn and MDm embryos, the decreased Shh expression in the MD offspring is of particular interest in relation to the findings of embryonic craniofacial (56) and aortic (57) anomalies resulting from direct inhibition of Shh, as well as the findings of an early role for Shh in securing the neural crest cell survival in the early development of the lower jaw (58).
Negative_regulation (inhibition) of Shh in lower jaw
5) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.58 Pain Relevance 0.03
Histological studies at eight weeks after cell transplantation showed a marked reduction in infarct size and preservation of host myocardium in ShhMSCs transplanted group as compared with EmpMSC and DMEM groups.
Negative_regulation (reduction) of ShhMSCs in myocardium
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0.03
Another interesting finding in the present study was the presence of PKM fragment of PKC in ShhMSCs at 72-h after transfection with Shh plasmid.
Negative_regulation (presence) of ShhMSCs
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.08 Pain Relevance 0.03
At fused stage, early markers for osteoblasts and chondrocytes (runx2, osterix, sox9 and bmp2) were upregulated whereas the osteoblast inhibitor (twist) and genes involved in chondrocyte hypertrophy (bmp4, mef2c, col10a, shh and ihh) were downregulated, results also supported by ISH.
Negative_regulation (downregulated) of shh in osteoblast associated with hypertrophy and osteoporosis
8) Confidence 0.09 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.45 Pain Relevance 0

General Comments

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