INT253193

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) cell differentiation (Ros1) nuclear envelope (Parp1)
protein complex (Parp1) cell proliferation (Ros1) nucleolus (Parp1)
Ros1 (Rattus norvegicus)
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 91.96 High High
Inflammation 2 22.48 Low Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 50 98.76 Very High Very High Very High
Congenital Anomalies 8 80.84 Quite High
Gestational Diabetes 9 73.92 Quite High
Fetal Diseases 2 62.84 Quite High
Apoptosis 10 50.00 Quite Low
INFLAMMATION 2 22.48 Low Low
Stress 5 5.00 Very Low Very Low Very Low
Exencephaly /

Neural Tube Defects

2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The previously demonstrated diabetes-induced decrease in GAPDH enzyme activity (33) may thus be a ROS-mediated alteration of the GAPDH enzyme itself (either directly or via DNA damageĀ–induced PARP activity) (32), thereby causing a block in the glycolytic pathway with a number of metabolic effects with teratological importance, such as diacylglycerol-mediated activation of (several isoforms of) protein kinase C (37,38), increased hexosamine flux (36), and enhanced production of glycosylation precursors/products (39).
ROS Regulation (alteration) of PARP associated with kinase c and diabetes mellitus
1) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.57 Pain Relevance 0.05

General Comments

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