INT2532

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Context Info
Confidence 0.00
First Reported 1975
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 98
Total Number 100
Disease Relevance 53.06
Pain Relevance 28.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cebpz)
Anatomy Link Frequency
blood 16
cortex 5
brain 3
neuronal 3
MCA 2
Cebpz (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 94 100.00 Very High Very High Very High
anesthesia 140 99.98 Very High Very High Very High
Morphine 18 99.98 Very High Very High Very High
ischemia 293 99.84 Very High Very High Very High
narcan 32 99.74 Very High Very High Very High
Somatosensory cortex 53 99.72 Very High Very High Very High
halothane 21 99.64 Very High Very High Very High
cva 114 99.60 Very High Very High Very High
qutenza 6 99.52 Very High Very High Very High
Migraine 28 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 98 100.00 Very High Very High Very High
Depression 80 100.00 Very High Very High Very High
Hypocapnia 94 99.98 Very High Very High Very High
Pressure Volume 2 Under Development 58 99.94 Very High Very High Very High
Injury 64 99.92 Very High Very High Very High
Cv General 4 Under Development 145 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 64 99.84 Very High Very High Very High
Migraine With Aura 16 99.72 Very High Very High Very High
Cv Unclassified Under Development 171 99.68 Very High Very High Very High
Hypercapnia 15 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decrease of rCBF was noted in bilateral subcallosal gyrus, superior temporal gyrus (STG) and bilateral anterior cingulate gyrus (ACG).
Negative_regulation (Decrease) of rCBF in anterior
1) Confidence 0.00 Published 2006 Journal Ann Nucl Med Section Body Doc Link 16856574 Disease Relevance 0 Pain Relevance 0
In two cases (22.2%), decreased rCBF was accompanied by slow waves.
Negative_regulation (decreased) of rCBF
2) Confidence 0.00 Published 2010 Journal J Clin Neurophysiol Section Abstract Doc Link 20505374 Disease Relevance 0 Pain Relevance 0.40
Strikingly, when measurements were repeated 5 days later, CBF was dramatically reduced in hypoxia (93.2+/-8.1 ml/100 g/min) compared with the first imaging session.
Negative_regulation (reduced) of CBF associated with hypoxia and imagery
3) Confidence 0.59 Published 2008 Journal NMR Biomed Section Abstract Doc Link 18275045 Disease Relevance 0.62 Pain Relevance 0.38
Baseline CBF in the right cortex was unaffected by a left-sided CSD, but decreased by 12% for left cortical application of tetrodotoxin.
Negative_regulation (decreased) of CBF in cortex associated with tetrodotoxin and depression
4) Confidence 0.51 Published 2004 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15241179 Disease Relevance 0.60 Pain Relevance 0.84
The consequent blood pressure fall reduced CBF to 77% of control as measured by the laser-Doppler technique.
Negative_regulation (reduced) of CBF in blood
5) Confidence 0.51 Published 1989 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 2738117 Disease Relevance 0.26 Pain Relevance 0.31
In adult rats, stimulation at 5-30 Hz produced frequency-dependent decreases in CBF of as much as 31+/-4% (at 30 Hz).
Negative_regulation (decreases) of CBF
6) Confidence 0.51 Published 2009 Journal Auton Neurosci Section Abstract Doc Link 19201662 Disease Relevance 0 Pain Relevance 0.09
In contrast, CBF autoregulation was impaired with 2 MAC sevoflurane.
Negative_regulation (impaired) of CBF
7) Confidence 0.43 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9768782 Disease Relevance 0.26 Pain Relevance 0.22
CBF and CMRo2 were maximally depressed by 50 and 35%, respectively, in rats given fentanyl 100 micrograms/kg compared with nitrous oxide-oxygen ventilated controls.
Negative_regulation (depressed) of CBF
8) Confidence 0.43 Published 1982 Journal Anesthesiology Section Abstract Doc Link 7137618 Disease Relevance 0.05 Pain Relevance 0
The drug decreased carotid blood flow and local cortical CBF, preceded in some experiments by short-lasting CBF increase.
Negative_regulation (decreased) of CBF in blood
9) Confidence 0.43 Published 1989 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2622296 Disease Relevance 0.07 Pain Relevance 0.07
CBF leveled off with decreasing hypoxia-induced pCO2 in awake rats, but monotonically decreased in anesthetized rats.
Negative_regulation (decreased) of CBF associated with hypoxia
10) Confidence 0.43 Published 2007 Journal Brain Res. Section Abstract Doc Link 17198686 Disease Relevance 1.50 Pain Relevance 0.30
Blockade of NMDA receptors in the NTS with D,L-2-amino-5-phosphonovalerate (AP5, 500 pmol) abolished the CBF decrease and CVR increase responses elicited by microinjection of NMDA into the NTS (n = 9).
Negative_regulation (decrease) of CBF in L-2 associated with nmda receptor
11) Confidence 0.43 Published 1994 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 7806768 Disease Relevance 0.25 Pain Relevance 0.21
Figure 1 shows that DKA rats had significantly reduced CBF, as measured by perfusion-weighted imaging.
Negative_regulation (reduced) of CBF associated with ketoacidosis and imagery
12) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 1.18 Pain Relevance 0.05
Most importantly, the current study demonstrates that CBF is indeed substantially decreased in rats with untreated DKA, consistent with our hypothesis that DKA-related CE is caused by cerebral hypoperfusion.
Negative_regulation (decreased) of CBF associated with pressure and volume under development and ketoacidosis
13) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 2.16 Pain Relevance 0.06
Surprisingly, hypoxia also decreased CBF likely because hypoxia induced hypocapnia.
Negative_regulation (decreased) of CBF associated with hypocapnia and hypoxia
14) Confidence 0.38 Published 2007 Journal Brain Res. Section Abstract Doc Link 17198686 Disease Relevance 1.30 Pain Relevance 0.30
Baseline CBF in the right cortex was unaffected by a left-sided CSD, but decreased by 12% for left cortical application of tetrodotoxin.
Neg (unaffected) Negative_regulation (unaffected) of CBF in cortex associated with tetrodotoxin and depression
15) Confidence 0.38 Published 2004 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15241179 Disease Relevance 0.59 Pain Relevance 0.83
Hypoxia-induced CBF and BOLD decreases were smaller in awake, relative to anesthetized, rats at low pO2, but similar at high pO2.
Negative_regulation (decreases) of CBF associated with hypoxia
16) Confidence 0.38 Published 2007 Journal Brain Res. Section Abstract Doc Link 17198686 Disease Relevance 1.38 Pain Relevance 0.29
Thus, transhemispheric diaschisis produced a pronounced decrease in the spontaneous spike rate accompanied by no reduction or a small reduction in basal CBF, and an attenuation in amplitudes of evoked synaptic responses and corresponding rises in CBF.
Negative_regulation (reduction) of CBF in spike
17) Confidence 0.38 Published 2004 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15241179 Disease Relevance 0.44 Pain Relevance 0.76
CBF was severely decreased at the site of impact where necrosis developed later, and it remained depressed in the surrounding areas throughout the observation period.
Negative_regulation (decreased) of CBF associated with necrosis
18) Confidence 0.38 Published 2007 Journal Brain Res. Section Abstract Doc Link 17275796 Disease Relevance 0.58 Pain Relevance 0.14
Administration of sodium pentobarbital reduced CBF and CMRO2 by 66% +/- 16% and 61% +/- 6%, respectively (i.e., "deactivation").
Negative_regulation (reduced) of CBF
19) Confidence 0.38 Published 2000 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10724113 Disease Relevance 0 Pain Relevance 0.53
With use of microsurgical techniques, both pterygopalatine and external carotid arteries were occluded and the basilar artery was coagulated to reduce potential collateral CBF during ischemia.
Negative_regulation (reduce) of CBF in basilar artery associated with ischemia
20) Confidence 0.38 Published 1991 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 1939388 Disease Relevance 0.59 Pain Relevance 0.35

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