INT253325

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTHFR) small molecule metabolic process (MTHFR) oxidoreductase activity (MTHFR)
cellular amino acid metabolic process (MTHFR)
MTHFR (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 39 93.72 High High
rheumatoid arthritis 63 85.92 High High
Inflammation 35 62.16 Quite High
Bioavailability 1 47.68 Quite Low
adenocard 3 41.60 Quite Low
cytokine 28 5.00 Very Low Very Low Very Low
Infliximab 18 5.00 Very Low Very Low Very Low
Etanercept 18 5.00 Very Low Very Low Very Low
Adalimumab 8 5.00 Very Low Very Low Very Low
anakinra 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 10 97.88 Very High Very High Very High
Cancer 17 94.80 High High
Rheumatoid Arthritis 64 85.92 High High
Colon Cancer 99 71.92 Quite High
INFLAMMATION 38 62.16 Quite High
Diabetes Mellitus 1 28.88 Quite Low
Cardiovascular Disease 1 27.84 Quite Low
Disease 21 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 5 5.00 Very Low Very Low Very Low
Familial Adenomatous Polyposis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When folate levels are adequate, the reduced MTHFR activity induced by the same genotypes would lead to a great pool of methylenetetrahydrofolate available for DNA synthesis, and therefore prevent cancer by diminishing uracil misincorporation.
Positive_regulation (induced) of Negative_regulation (reduced) of MTHFR associated with cancer
1) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.68 Pain Relevance 0.06
The A1298C polymorphism also results in decreased MTHFR activity and exhibits other discrepancies in its clinical effects.
Positive_regulation (results) of Negative_regulation (decreased) of MTHFR
2) Confidence 0.22 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.55 Pain Relevance 0.44

General Comments

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