INT253327

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTHFR) small molecule metabolic process (MTHFR) oxidoreductase activity (MTHFR)
cellular amino acid metabolic process (MTHFR)
MTHFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 40 62.16 Quite High
chemokine 2 32.00 Quite Low
cINOD 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 198 99.56 Very High Very High Very High
Cancer 32 94.80 High High
INFLAMMATION 40 62.16 Quite High
Diabetes Mellitus 2 28.88 Quite Low
Cardiovascular Disease 2 27.84 Quite Low
Adenoma 2 18.76 Low Low
Familial Adenomatous Polyposis 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Hereditary Nonpolyposis Colorectal Neoplasms 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When folate levels are adequate, the reduced MTHFR activity induced by the same genotypes would lead to a great pool of methylenetetrahydrofolate available for DNA synthesis, and therefore prevent cancer by diminishing uracil misincorporation.
Negative_regulation (reduced) of Positive_regulation (induced) of MTHFR associated with cancer
1) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.68 Pain Relevance 0.06
Two polymorphisms c.665C>T (also reported as C677T) and c.1286A>C (aka c.1298A>C), have been widely tested for modification of CRC risk, because of the reduction in MTHFR activity induced by their minor allele.
Negative_regulation (reduction) of Positive_regulation (induced) of MTHFR associated with colon cancer
2) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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