INT25335

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Context Info
Confidence 0.21
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
neurons 2
Pla2g2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1 88.64 High High
Paracetamol 3 76.00 Quite High
imagery 1 75.00 Quite High
agonist 1 62.48 Quite High
fluoxetine 1 48.48 Quite Low
sSRI 1 47.36 Quite Low
Sciatica 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Death 1 98.50 Very High Very High Very High
Injury 5 98.30 Very High Very High Very High
Apoptosis 3 97.68 Very High Very High Very High
INFLAMMATION 1 88.64 High High
Hepatotoxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies have shown that 5-HT2 receptors can be coupled via G-proteins to phospholipase A2 (PLA2) activation, releasing arachidonic acid from phospholipids.
Positive_regulation (coupled) of Positive_regulation (activation) of PLA2
1) Confidence 0.21 Published 2003 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 12928041 Disease Relevance 0 Pain Relevance 0.07
Compared to the control group, the compression group showed a significant decrease in the number of the HRP-labeled cells and a significant increase in levels of PGE2 and PLA2, in the expression of VEGF protein, and in the number of apoptotic DRG neurons.
Positive_regulation (increase) of Positive_regulation (increase) of PLA2 in neurons associated with apoptosis
2) Confidence 0.06 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19191544 Disease Relevance 0.38 Pain Relevance 0.04
This paper describes work on a proposed hypothesis of cell injury and death in which an hepatotoxin-induced rise in cytosolic free Ca2+ concentration activates phospholipase A2 (PLA2) resulting in the release of arachidonic acid (A.A.) from membrane phospholipids.
Positive_regulation (activates) of Positive_regulation (activates) of PLA2 associated with injury and death
3) Confidence 0.05 Published 1989 Journal Eicosanoids Section Abstract Doc Link 2516744 Disease Relevance 0.42 Pain Relevance 0.22

General Comments

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