INT25336

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Context Info
Confidence 0.72
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.97
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
blood 1
Pla2g2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 43 97.38 Very High Very High Very High
Inflammation 28 95.48 Very High Very High Very High
Inflammatory response 6 91.04 High High
Inflammatory mediators 31 86.60 High High
cINOD 1 85.16 High High
Paracetamol 3 83.32 Quite High
antagonist 1 75.76 Quite High
cytokine 6 55.20 Quite High
Bile 18 5.00 Very Low Very Low Very Low
medulla 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obstructive Jaundice 85 99.96 Very High Very High Very High
Pancreatitis 131 99.82 Very High Very High Very High
Apoptosis 85 98.56 Very High Very High Very High
Injury 19 97.76 Very High Very High Very High
INFLAMMATION 64 95.48 Very High Very High Very High
Granuloma 1 91.40 High High
Hepatotoxicity 2 84.32 Quite High
Multiple Organ Failure 11 83.92 Quite High
Adhesions 1 79.56 Quite High
Arthus Reaction 1 75.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone treatment significantly reduced all parameters determined, whereas p-bromophenacyl bromide had a significant inhibitory effect on PLA2 activity and PGE2 release, and indomethacin only restored PGE2 levels.
Localization (release) of PLA2 associated with dexamethasone
1) Confidence 0.72 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8375942 Disease Relevance 0.49 Pain Relevance 0.34
After treatment with Salvia miltiorrhizae, the contents of PLA2 in treated group were significantly lower than those in model control group, indicating that Salvia miltiorrhizae can effectively reduce the contents of PLA2 via a mechanism that may be associated with inhibiting the release of PLA2 from lysosomes.
Localization (release) of PLA2
2) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 0.77 Pain Relevance 0
,

and PLA2 in serum

Localization (serum) of PLA2
3) Confidence 0.35 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 1.60 Pain Relevance 0.37
In SAP and OJ, PLA2 is activated and massively released into the blood.
Localization (released) of PLA2 in blood associated with pancreatitis and obstructive jaundice
4) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.76 Pain Relevance 0.22
The data presented support the proposed sequence of events in which A.A., released from membrane phospholipids by Ca2(+)-activated PLA2, acts as substrate for the synthesis of cytodestructive eicosanoids.
Localization (released) of PLA2
5) Confidence 0.09 Published 1989 Journal Eicosanoids Section Abstract Doc Link 2516744 Disease Relevance 0.36 Pain Relevance 0.24

General Comments

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