INT253370

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) intracellular (Lep) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
neuronal 1
Lep (Rattus norvegicus)
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 10 65.60 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 78 98.20 Very High Very High Very High
Appetite Loss 28 82.00 Quite High
Body Weight 8 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing evidence shows that leptin and IL-6 activates AMPK in the peripheral tissues, such as skeletal muscle and adipose tissue, increasing fatty acid oxidation and glucose uptake in these tissues [40]–[42], however, leptin has an opposing effect in hypothalamic tissue, reducing neuronal AMPK activity [12], [43].
leptin Negative_regulation (reducing) of AMPK in neuronal associated with obesity
1) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.18 Pain Relevance 0
Leptin reduced AMPK and ACC phosphorylation levels in the hypothalami of control and exercised rats.
Leptin Negative_regulation (reduced) of AMPK
2) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03

General Comments

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