INT253377

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.24
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) intracellular (Lep) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
hypothalamus 2
Lep (Rattus norvegicus)
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 15 65.60 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 117 99.86 Very High Very High Very High
Appetite Loss 42 61.36 Quite High
Body Weight 12 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leptin reduced AMPK and ACC phosphorylation levels in the hypothalami of control and exercised rats.
Leptin Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK
1) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
In exercised DIO rats, leptin reduced the phosphorylation of AMPK by 65% and ACC by 37%, compared to DIO rats at rest and the i.c.v. pretreatment with anti-IL6 antibody before the exercise protocol, reversed the suppressive effects of leptin on AMPK/ACC pathway in the hypothalamus of exercised DIO rats (Figures 7c and d).
leptin Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK in hypothalamus associated with obesity
2) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 1.18 Pain Relevance 0
Comparing leptin-treated groups (control vs. exercise), in exercised animals, leptin reduced both AMPK threonine phosphorylation and ACC serine phosphorylation of 57% and 45%, respectively (Figures 5b and c).
leptin Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK
3) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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