INT253386

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.37
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
myocardium 1
hypothalamus 1
Eif4ebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 15 97.44 Very High Very High Very High
Inflammation 3 81.24 Quite High
agonist 6 14.40 Low Low
cytokine 13 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
nalbuphine 3 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 118 98.36 Very High Very High Very High
Hyperglycemia 2 90.72 High High
Diabetes Mellitus 7 90.00 High High
Appetite Loss 42 89.44 High High
Hyperplasia 4 82.56 Quite High
INFLAMMATION 3 81.24 Quite High
Cardiovascular Disease 2 80.80 Quite High
Insulin Resistance 2 76.00 Quite High
Neointima 11 19.00 Low Low
Injury 16 17.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, while levels of p70 S6K and 4E-BP1 were not examined as part of the previous study, phosphorylation of other downstream targets of AKT kinase activity, namely Foxo1 and Foxo3, were shown to be similarly reduced.
Spec (examined) Gene_expression (levels) of 4E-BP1
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
AMPK, ACC, p70S6K and 4EBP1 protein expression (Figures 4b–e, lower panels).


Gene_expression (expression) of 4EBP1
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.07
6 M) to rats pretreated with AICAR reduced both p70S6K and 4EBP1 phosphorylation levels in the hypothalamus.
Gene_expression (levels) of 4EBP1 in hypothalamus
3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
The p70S6K and 4EBP1 protein levels were not different between the groups (Figures 7e and f, lower panels).


Gene_expression (levels) of 4EBP1
4) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.72 Pain Relevance 0
In contrast, elevations in phosphorylation of p70 S6K residues Thr421/Ser424, and 4E-BP1 residues Thr37/Thr46 (P<0.05), consistent with an elevation in translation initiation, were seen exclusively in the myocardium of LPS-treated animals.


Gene_expression (residues) of 4E-BP1 in myocardium
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Protein and phosphorylation levels of AKT, p70 S6K and 4E-BP1
Gene_expression (levels) of 4E-BP1
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Insulin induces increased expression of translation initiation factors and phosphorylation of 4EBP-1 and S6K, critical cell cycle regulators downstream of mTOR.
Gene_expression (expression) of 4EBP-1
7) Confidence 0.02 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.65 Pain Relevance 0.04

General Comments

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