INT253390

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 0.76
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
hypothalamus 2
respiratory 2
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 15 87.20 High High
cytokine 7 64.88 Quite High
Kinase C 4 35.68 Quite Low
imagery 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
qutenza 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 42 95.24 Very High Very High Very High
Obesity 117 93.08 High High
Hepatocellular Cancer 4 73.72 Quite High
Targeted Disruption 4 63.12 Quite High
Stress 88 22.16 Low Low
Body Weight 12 5.00 Very Low Very Low Very Low
Parkinson's Disease 8 5.00 Very Low Very Low Very Low
Immunization 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, AMPK activity is diminished in IL-6 deficient mice at rest and the absolute increases in AMPK activity in these tissues caused by exercise is diminished compared with control mice [27].
Negative_regulation (diminished) of Positive_regulation (increases) of AMPK
1) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.09 Pain Relevance 0.03
Treatment with leptin markedly reduced food intake, AMPK activity and increased mTOR activity in exercised rats that were pretreated with vehicle, although no increase in response to leptin-induced anorexia and modulation of AMPK/mTOR pathway were detected after i.c.v. pretreatment with anti-IL-6 antibody.
Negative_regulation (reduced) of Positive_regulation (increased) of AMPK associated with appetite loss
2) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.16 Pain Relevance 0
Furthermore, the reduction of AMPK and ACC phosphorylation and increase in phosphorylation of proteins involved in mTOR signal transduction, observed in the hypothalamus after leptin infusion, were more pronounced in both lean and diet-induced obesity rats after acute exercise.
Negative_regulation (reduction) of Positive_regulation (increase) of AMPK in hypothalamus associated with obesity
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2585815 Disease Relevance 0.26 Pain Relevance 0.04
In these cells, AMPK activation by metformin was blocked by quinidine, a competitive inhibitor of OCT1.
Negative_regulation (blocked) of Positive_regulation (activation) of AMPK
4) Confidence 0.19 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.06 Pain Relevance 0
Interestingly, AMPK activation in response to phenformin or galegine was not blocked by quinidine, indicating that their cellular uptake is not dependent on the transporter.
Negative_regulation (blocked) of Positive_regulation (activation) of AMPK
5) Confidence 0.19 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.06 Pain Relevance 0
As expected, in H4IIE cells quinidine almost completely blocked AMPK activation, as well as the phosphorylation of theĀ AMPK target, ACC, by metformin.
Negative_regulation (blocked) of Positive_regulation (activation) of AMPK
6) Confidence 0.19 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.07 Pain Relevance 0
The experiments in Figures 6 show that inhibition of the respiratory chain in H4IIE cells was almost maximal after 2 hr, as was AMPK activation.
Negative_regulation (maximal) of Positive_regulation (activation) of AMPK in respiratory
7) Confidence 0.12 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.06 Pain Relevance 0

General Comments

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