INT253391

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 0.39
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 54 78.00 Quite High
Hippocampus 151 75.12 Quite High
Glutamate receptor 6 68.16 Quite High
agonist 18 42.80 Quite Low
metalloproteinase 5 25.68 Quite Low
Catecholamine 2 19.04 Low Low
antagonist 18 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Intracerebroventricular 10 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 28 89.08 High High
Obesity 78 70.08 Quite High
Aging 8 63.76 Quite High
Shock 24 5.00 Very Low Very Low Very Low
Disease 19 5.00 Very Low Very Low Very Low
Amnesia 18 5.00 Very Low Very Low Very Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Decapitation 12 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In considering the role of local protein synthesis in synaptic plasticity underlying memory processing [21], [62], [63], the present results raise several questions: What are the upstream extracellular signals that mediate activation of mTOR signaling required for memory formation?
Positive_regulation (mediate) of Positive_regulation (activation) of mTOR
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.08
In considering the role of local protein synthesis in synaptic plasticity underlying memory processing [21], [62], [63], the present results raise several questions: What are the upstream extracellular signals that mediate activation of mTOR signaling required for memory formation?
Positive_regulation (required) of Positive_regulation (activation) of mTOR
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.09
These results show that BDNF is the extracellular signal triggering mTOR activation 3 h after training.


Positive_regulation (triggering) of Positive_regulation (activation) of mTOR
3) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03
We began to answer these questions by examining whether BDNF triggers the activation of mTOR induced by IA training.
Spec (whether) Positive_regulation (induced) of Spec (whether) Positive_regulation (activation) of mTOR
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.11
We began to answer these questions by examining whether BDNF triggers the activation of mTOR induced by IA training.
Spec (whether) Positive_regulation (activation) of Spec (whether) Positive_regulation (induced) of mTOR
5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.11
45 h after training hindered the IA learning-induced increase in mTOR (Figure 5C) and p70S6K (Figure 5D) phosphorylation that takes place 3 h after training.
Positive_regulation (induced) of Positive_regulation (increase) of mTOR
6) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03
Furthermore, settings of activation of AMPK or inactivation of mTOR were selected to induce changes in target protein phosphorylation, but not food intake.
Positive_regulation (activation) of Positive_regulation (inactivation) of mTOR
7) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.27 Pain Relevance 0
Finally, exercise induced increased responsiveness of leptin stimulated mTOR signaling was reverted by rapamycin.
Positive_regulation (increased) of Positive_regulation (stimulated) of mTOR
8) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.12 Pain Relevance 0
Activation of mTOR induces translation of different mRNA through its downstream targets such as the ribosomal p70S6 kinase and the initiation factor 4E-binding protein 1 [46].
Positive_regulation (induces) of Positive_regulation (Activation) of mTOR
9) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0

General Comments

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