INT253392

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.26
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
dorsal 2
hypothalamus 2
Mtor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 5 85.36 High High
Hippocampus 50 64.72 Quite High
Glutamate receptor 2 58.48 Quite High
long-term potentiation 18 24.16 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 39 95.00 High High
Appetite Loss 14 90.28 High High
Shock 8 5.00 Very Low Very Low Very Low
Amnesia 6 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
45 h after training hindered the IA learning-induced increase in mTOR (Figure 5C) and p70S6K (Figure 5D) phosphorylation that takes place 3 h after training.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03
We found that blockade of BDNF with function-blocking anti-BDNF antibodies delivered into dorsal CA1 15 min before training abolished the IA learning-induced increase in mTOR (Figure 5A) and p70S6K (Figure 5B) phosphorylation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of mTOR in dorsal
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.06
Furthermore, the reduction of AMPK and ACC phosphorylation and increase in phosphorylation of proteins involved in mTOR signal transduction, observed in the hypothalamus after leptin infusion, were more pronounced in both lean and diet-induced obesity rats after acute exercise.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of mTOR in hypothalamus associated with obesity
3) Confidence 0.34 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2585815 Disease Relevance 0.26 Pain Relevance 0.04

General Comments

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