INT253395

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 1.35
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
hypothalamus 6
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 40 76.28 Quite High
agonist 8 60.04 Quite High
anesthesia 16 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 312 95.52 Very High Very High Very High
Stress 66 91.12 High High
Appetite Loss 112 75.92 Quite High
Hepatocellular Cancer 3 73.72 Quite High
Aging 8 71.12 Quite High
Body Weight 32 31.48 Quite Low
Parkinson's Disease 6 5.00 Very Low Very Low Very Low
Immunization 3 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As previously shown [43], exercise, per se, does not alter AMPK activity in the hypothalamus; however, we observed that the normal inhibition of AMPK phosphorylation and activity in the hypothalamus, induced by leptin administration, was improved in both lean and diet-induced obesity rats after acute protocol of exercise.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of AMPK in hypothalamus associated with obesity
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.31 Pain Relevance 0
Comparing AICAR treated groups (control vs. exercise), exercised animals showed reductions in AMPK threonine and ACC serine phosphorylation of 52% and 31%, respectively.
Negative_regulation (reductions) of Phosphorylation (phosphorylation) of AMPK
2) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
6 M) to exercised rats pretreated with vehicle reduced AMPK and ACC phosphorylation in the hypothalamus by 63% and 60% respectively, compared with the control group.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK in hypothalamus
3) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.32 Pain Relevance 0
Leptin reduced AMPK and ACC phosphorylation levels in the hypothalami of control and exercised rats.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK
4) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
As well as in response to leptin, in the present study, we demonstrated that IL-6 alone reduced AMPK phosphorylation in the hypothalamus of rats.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK in hypothalamus
5) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.16 Pain Relevance 0
-LA reduced AMPK and ACC phosphorylation levels, in the hypothalami of control and exercised rats.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK
6) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.07
Comparing fasting treated groups (control vs. exercise), exercised animals showed reductions in AMPK threonine and ACC serine phosphorylation of 65% and 41%, respectively (Figures 3l and m).
Negative_regulation (reductions) of Phosphorylation (phosphorylation) of AMPK
7) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.05 Pain Relevance 0.04
Comparing leptin-treated groups (control vs. exercise), in exercised animals, leptin reduced both AMPK threonine phosphorylation and ACC serine phosphorylation of 57% and 45%, respectively (Figures 5b and c).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of AMPK
8) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.06 Pain Relevance 0.03
As expected, in H4IIE cells quinidine almost completely blocked AMPK activation, as well as the phosphorylation of theĀ AMPK target, ACC, by metformin.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of AMPK
9) Confidence 0.14 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.07 Pain Relevance 0
Second, our results are consistent with the idea that 2-deoxyglucose acts by inhibiting glycolysis, because it caused phosphorylation and activation of AMPK in WT but not RG cells and increased cellular ADP:ATP ratios but did not affect oxygen uptake.
Negative_regulation (caused) of Phosphorylation (phosphorylation) of AMPK
10) Confidence 0.12 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.23 Pain Relevance 0
As expected, in H4IIE cells quinidine almost completely blocked AMPK activation, as well as the phosphorylation of theĀ AMPK target, ACC, by metformin.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of AMPK
11) Confidence 0.12 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.07 Pain Relevance 0

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