INT253396

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
hypothalamus 1
Eif4ebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 56.20 Quite High
Intracerebroventricular 10 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nalbuphine 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 28 37.32 Quite Low
Obesity 78 29.28 Quite Low
Heart Rate Under Development 10 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Sepsis 6 5.00 Very Low Very Low Very Low
Myocardial Infarction 4 5.00 Very Low Very Low Very Low
Coronary Heart Disease 2 5.00 Very Low Very Low Very Low
Muscular Atrophy 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein and phosphorylation levels of AKT, p70 S6K and 4E-BP1
Negative_regulation (levels) of 4E-BP1
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
0.097), and moreover, elements examined downstream of AKT (phosphorylation levels of p70 S6K and 4E-BP1) were unchanged by the LPS treatment protocol described here.
Negative_regulation (levels) of 4E-BP1
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
AICAR reduced p70S6K and 4EBP1 threonine phosphorylation levels in the hypothalamus of control and exercised rats.
Negative_regulation (reduced) of 4EBP1 in hypothalamus
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.03
Exercised animals pretreated with Rapamycin also reduced hypothalamic p70S6K and 4EBP1 phosphorylation (Figures 8d and e).
Negative_regulation (reduced) of 4EBP1
4) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0

General Comments

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