INT253401

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 10
Disease Relevance 1.39
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
hypothalamus 2
respiratory 2
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 9 93.36 High High
cytokine 10 61.40 Quite High
Kinase C 9 58.00 Quite High
imagery 18 5.00 Very Low Very Low Very Low
Intracerebroventricular 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 198 97.04 Very High Very High Very High
Hepatocellular Cancer 9 94.12 High High
Parkinson's Disease 18 90.96 High High
Targeted Disruption 9 85.44 High High
Hypertrophy 9 80.00 Quite High
Diabetes Mellitus 9 71.04 Quite High
Obesity 39 66.20 Quite High
Hypoxia 9 55.92 Quite High
Appetite Loss 14 51.80 Quite High
Shock 9 50.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the hypothalamus, activation of AMPK leads to increased feeding, thereby increasing energy intake.
Positive_regulation (increased) of Positive_regulation (activation) of AMPK in hypothalamus
1) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.12 Pain Relevance 0
These agents caused phosphorylation and activation of AMPK only in WT and not in RG cells, inhibited cellular oxygen uptake, and (apart from metformin) significantly increased ADP:ATP ratios.
Neg (not) Positive_regulation (caused) of Positive_regulation (activation) of AMPK
2) Confidence 0.15 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.09 Pain Relevance 0
In these cells, activation of endogenous AMPK by metformin was much more rapid, reaching a maximum after 2–3 hr with a half-maximal effect at 1.1 mM (data not shown), consistent with a reported Km of OCT1 for metformin of 1.5 mM (Koepsell et al., 2007).
Positive_regulation (reaching) of Positive_regulation (activation) of AMPK
3) Confidence 0.15 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.09 Pain Relevance 0
First, hydrogen peroxide caused activation and phosphorylation of AMPK in WT but not in RG cells, increased the ADP:ATP ratio, and inhibited whole-cell oxygen uptake with no effect of subsequent DNP addition.
Positive_regulation (caused) of Positive_regulation (activation) of AMPK
4) Confidence 0.13 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.09 Pain Relevance 0
It is a challenge to understand how such a variety of compounds with different structures all lead to AMPK activation, and various suggestions have been made.
Positive_regulation (lead) of Positive_regulation (activation) of AMPK
5) Confidence 0.13 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.22 Pain Relevance 0.12
While it caused activation of AMPK in RG cells, this was significantly less than that observed in WT cells.
Positive_regulation (caused) of Positive_regulation (activation) of AMPK
6) Confidence 0.13 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.25 Pain Relevance 0
We felt that it was important to develop a more sensitive diagnostic test to determine whether or not activation of AMPK by different agents was AMP dependent.
Spec (whether) Positive_regulation (dependent) of Spec (whether) Positive_regulation (activation) of AMPK
7) Confidence 0.13 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.13 Pain Relevance 0
Second, our results are consistent with the idea that 2-deoxyglucose acts by inhibiting glycolysis, because it caused phosphorylation and activation of AMPK in WT but not RG cells and increased cellular ADP:ATP ratios but did not affect oxygen uptake.
Positive_regulation (caused) of Positive_regulation (activation) of AMPK
8) Confidence 0.13 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.23 Pain Relevance 0
All three agents caused a robust activation of AMPK in WT cells.
Positive_regulation (caused) of Positive_regulation (activation) of AMPK
9) Confidence 0.13 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.07 Pain Relevance 0
A surprising finding was that metformin caused a rather severe inhibition of the respiratory chain in HEK293 cells (Figure 6B), but caused only a modest activation of AMPK without significant changes in ADP:ATP.
Positive_regulation (caused) of Positive_regulation (activation) of AMPK in respiratory
10) Confidence 0.13 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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