INT253402

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
hypothalamus 1
respiratory 1
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 44 93.44 High High
Obesity 39 73.68 Quite High
Appetite Loss 14 30.08 Quite Low
Parkinson's Disease 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Immunization 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Hypertrophy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, these findings provide support to the hypothesis that AMPK and mTOR interact in the hypothalamus to control feeding in exercised rats, in an IL-6-dependent manner.


AMPK Binding (interact) of in hypothalamus
1) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.26 Pain Relevance 0
According to this model, the phosphorylation state of AMPK in unstressed WT cells is low because the majority of the complexes have ATP, rather than AMP, bound to the ?
AMPK Binding (bound) of
2) Confidence 0.14 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0 Pain Relevance 0
In summary, the use of WT and RG cells allows us to distinguish several different mechanisms by which AMPK can be activated, of which the first three cause indirect activation by increasing cellular AMP: (1) inhibition of the respiratory chain (biguanides, galegine, troglitazone, phenobarbital, berberine), (2) inhibition of the mitochondrial ATP synthase (oligomycin, resveratrol), (3) inhibition of glycolysis (2-deoxyglucose), (4) increasing cytoplasmic Ca2+ (A23187), (5) intracellular conversion into an AMP mimetic (AICAR), and (6) direct binding to AMPK at a site distinct from the AMP site (A769662).
AMPK Binding (binding) of in respiratory
3) Confidence 0.12 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.17 Pain Relevance 0

General Comments

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