INT253402

Context Info Confidence 0.24 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.43 Pain Relevance 0

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2) protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)

Anatomy Link Frequency hypothalamus 1 respiratory 1 Prkaa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Intracerebroventricular 5 5.00 imagery 4 5.00 cytokine 3 5.00 Kinase C 2 5.00 anesthesia 2 5.00 qutenza 2 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat Stress 44 93.44 Obesity 39 73.68 Appetite Loss 14 30.08 Parkinson's Disease 4 5.00 Body Weight 4 5.00 Immunization 2 5.00 Diabetes Mellitus 2 5.00 Hypoxia 2 5.00 Targeted Disruption 2 5.00 Hypertrophy 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, these findings provide support to the hypothesis that AMPK and mTOR interact in the hypothalamus to control feeding in exercised rats, in an IL-6-dependent manner.

AMPK Binding (interact) of in hypothalamus

1) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.26 Pain Relevance 0

According to this model, the phosphorylation state of AMPK in unstressed WT cells is low because the majority of the complexes have ATP, rather than AMP, bound to the ?

AMPK Binding (bound) of

2) Confidence 0.14 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0 Pain Relevance 0

In summary, the use of WT and RG cells allows us to distinguish several different mechanisms by which AMPK can be activated, of which the first three cause indirect activation by increasing cellular AMP: (1) inhibition of the respiratory chain (biguanides, galegine, troglitazone, phenobarbital, berberine), (2) inhibition of the mitochondrial ATP synthase (oligomycin, resveratrol), (3) inhibition of glycolysis (2-deoxyglucose), (4) increasing cytoplasmic Ca2+ (A23187), (5) intracellular conversion into an AMP mimetic (AICAR), and (6) direct binding to AMPK at a site distinct from the AMP site (A769662).

AMPK Binding (binding) of in respiratory

3) Confidence 0.12 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.17 Pain Relevance 0

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