INT253403

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.07
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il6st) extracellular space (Il6st) cellular_component (Il6st)
Anatomy Link Frequency
astrocytes 1
Il6st (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 15 99.60 Very High Very High Very High
Neuropathic pain 36 99.46 Very High Very High Very High
cytokine 3 97.04 Very High Very High Very High
Spinal cord 174 90.12 High High
Pain 28 88.96 High High
Peripheral nerve injury 2 74.92 Quite High
glial activation 4 51.76 Quite High
allodynia 44 50.00 Quite Low
Central nervous system 56 45.60 Quite Low
c fibre 20 41.00 Quite Low
Disease Link Frequency Relevance Heat
Cicatrix 24 99.70 Very High Very High Very High
Neuropathic Pain 80 99.46 Very High Very High Very High
Spinal Cord Injury 134 90.40 High High
Syndrome 18 89.36 High High
Pain 22 88.96 High High
Leukemia 2 76.32 Quite High
Nervous System Injury 2 74.92 Quite High
Obesity 39 74.04 Quite High
Injury 268 60.64 Quite High
Hyperalgesia 24 28.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
subunit of its receptor triggers the recruitment of gp130, subsequently leading to the activation of the gp130-associated JAK [29]–[31].
Positive_regulation (activation) of gp130
1) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.05
In contrast, GRPs grown in the presence of the gp130 receptor agonist CNTF generate GFAP+ astrocytes (GDAsCNTF) with processes that are labeled by A2B5 [17].
Positive_regulation (presence) of gp130 in astrocytes associated with agonist
2) Confidence 0.14 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.55 Pain Relevance 0.39
Neuropathic pain, glial scar formation and gp130 receptor activation
Positive_regulation (activation) of gp130 associated with cicatrix and neuropathic pain
3) Confidence 0.13 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.44 Pain Relevance 1.10

General Comments

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