INT253404

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 1.23
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
hypothalamus 2
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 8 92.20 High High
cytokine 10 6.64 Low Low
imagery 16 5.00 Very Low Very Low Very Low
Intracerebroventricular 10 5.00 Very Low Very Low Very Low
qutenza 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 176 92.12 High High
Parkinson's Disease 16 90.96 High High
Cancer 8 84.08 Quite High
Hepatocellular Cancer 8 73.20 Quite High
Appetite Loss 28 70.04 Quite High
Targeted Disruption 8 66.16 Quite High
Obesity 78 62.00 Quite High
Shock 8 28.40 Quite Low
Hypoxia 8 17.44 Low Low
Immunization 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
6 M) to rats pretreated with AICAR increased both AMPK and ACC phosphorylation levels in the hypothalamus (Figures 8b and c).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of AMPK in hypothalamus
1) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.11 Pain Relevance 0
The administration of AICAR increased AMPK threonine and ACC serine phosphorylation, although at this dose, AICAR was not sufficient to induce significant an increase in food intake in exercised animals (data not shown).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of AMPK
2) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.24 Pain Relevance 0
These agents caused phosphorylation and activation of AMPK only in WT and not in RG cells, inhibited cellular oxygen uptake, and (apart from metformin) significantly increased ADP:ATP ratios.
Neg (not) Positive_regulation (caused) of Phosphorylation (phosphorylation) of AMPK
3) Confidence 0.23 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.09 Pain Relevance 0
Second, our results are consistent with the idea that 2-deoxyglucose acts by inhibiting glycolysis, because it caused phosphorylation and activation of AMPK in WT but not RG cells and increased cellular ADP:ATP ratios but did not affect oxygen uptake.
Positive_regulation (caused) of Phosphorylation (phosphorylation) of AMPK
4) Confidence 0.20 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.23 Pain Relevance 0
These agents caused phosphorylation and activation of AMPK only in WT and not in RG cells, inhibited cellular oxygen uptake, and (apart from metformin) significantly increased ADP:ATP ratios.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of AMPK
5) Confidence 0.16 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.09 Pain Relevance 0
It has also been proposed that resveratrol and quercetin activate the NAD-dependent histone deacetylase SIRT1, triggering deacetylation of LKB1 and phosphorylation of AMPK (Suchankova et al., 2009).
Positive_regulation (triggering) of Phosphorylation (phosphorylation) of AMPK
6) Confidence 0.14 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.07 Pain Relevance 0.05
As expected, in H4IIE cells quinidine almost completely blocked AMPK activation, as well as the phosphorylation of the AMPK target, ACC, by metformin.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of AMPK
7) Confidence 0.14 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.07 Pain Relevance 0
It has also been proposed that resveratrol and quercetin activate the NAD-dependent histone deacetylase SIRT1, triggering deacetylation of LKB1 and phosphorylation of AMPK (Suchankova et al., 2009).
Positive_regulation (deacetylation) of Phosphorylation (phosphorylation) of AMPK
8) Confidence 0.14 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.07 Pain Relevance 0.05
First, hydrogen peroxide caused activation and phosphorylation of AMPK in WT but not in RG cells, increased the ADP:ATP ratio, and inhibited whole-cell oxygen uptake with no effect of subsequent DNP addition.
Positive_regulation (caused) of Phosphorylation (phosphorylation) of AMPK
9) Confidence 0.13 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.09 Pain Relevance 0
AMP binding stimulates AMPK by two mechanisms: (1) allosteric activation of phosphorylated AMPK, and (2) inhibition of dephosphorylation of Thr-172 by protein phosphatases (Davies et al., 1995; Suter et al., 2006; Sanders et al., 2007b).
Positive_regulation (activation) of Phosphorylation (phosphorylated) of AMPK
10) Confidence 0.13 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.18 Pain Relevance 0

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