INT253417

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) cytosol (ATIC) mitochondrion (ATIC)
small molecule metabolic process (ATIC) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
Anatomy Link Frequency
hypothalamus 1
ATIC (Homo sapiens)
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 71.52 Quite High
Intracerebroventricular 10 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 78 96.68 Very High Very High Very High
Aging 2 90.24 High High
Appetite Loss 28 64.48 Quite High
Body Weight 8 22.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we did not observe any normal stimulation of AMPK activity by AICAR in the hypothalamus of exercised rats, indicating that AMPK pathway is disrupted.
AICAR Positive_regulation (stimulation) of AMPK in hypothalamus
1) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.31 Pain Relevance 0
Consistent with food intake, AICAR increased AMPK threonine and ACC serine phosphorylation levels in the hypothalami of control rats, whilst in exercised animals, AICAR did not change AMPK/ACC phosphorylation status (Figures 3b and c).
AICAR Positive_regulation (increased) of AMPK
2) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.04

General Comments

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