INT253422

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.45
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT5B) nucleoplasm (STAT5B) nucleus (STAT5B)
cytoplasm (STAT5B) signal transducer activity (STAT5B)
Anatomy Link Frequency
leukocytes 2
STAT5B (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 76.40 Quite High
cytokine 7 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 34 86.16 High High
Erythrocytosis 11 80.88 Quite High
Myelodysplastic Syndromes 15 79.52 Quite High
Pulmonary Disease 4 15.88 Low Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Failure To Thrive 3 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low
Respiratory Failure 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GM-CSF receptor function was impaired in both affected siblings, as shown by reduced GM-CSF–stimulated phosphorylation of STAT5 (Fig. 2 F) and failure of GM-CSF to increase CD11b levels on leukocytes from the patient compared with controls (Fig. 2 G).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of STAT5 in leukocytes
1) Confidence 0.23 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.09 Pain Relevance 0
Mutated receptor expression in EPOR-negative cells results in EPOR and Stat5 phosphorylation.
Negative_regulation (results) of Phosphorylation (phosphorylation) of Stat5
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2916842 Disease Relevance 0.37 Pain Relevance 0.04

General Comments

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