INT25344

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Context Info
Confidence 0.57
First Reported 1981
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 5.00
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
heart 2
macrophages 1
neurite 1
Plg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 100.00 Very High Very High Very High
Dorsal horn 14 97.96 Very High Very High Very High
Spinal cord 21 97.48 Very High Very High Very High
Angina 6 96.80 Very High Very High Very High
Hippocampus 17 96.64 Very High Very High Very High
Demyelination 2 95.52 Very High Very High Very High
Inflammation 29 93.84 High High
Peripheral nervous system 9 93.84 High High
Glutamate 13 93.60 High High
anesthesia 1 93.28 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 15 99.68 Very High Very High Very High
Myocardial Infarction 9 99.52 Very High Very High Very High
Cv General 3 Under Development 6 96.80 Very High Very High Very High
Demyelinating Disease 8 95.52 Very High Very High Very High
INFLAMMATION 33 93.84 High High
Death 9 93.08 High High
Cancer 6 92.64 High High
Necrosis 4 92.08 High High
Syndrome 1 89.84 High High
Experimental Autoimmune Neuritis 1 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vasopressin release by D-aspartic acid, morphine and prolyl-leucyl-glycinamide (PLG) in DI Brattleboro rats.
Localization (release) of PLG associated with morphine
1) Confidence 0.57 Published 1984 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 6145163 Disease Relevance 0 Pain Relevance 0.72
To evaluate the effects of the fibrinolytic system on the development of coronary heart disease (CHD), the level of released plasminogen activator was measured by venous occlusion in 60 CHD cases, and 20 healthy subjects.
Localization (released) of plasminogen in heart associated with coronary artery disease
2) Confidence 0.13 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517077 Disease Relevance 0.70 Pain Relevance 0.14
In acute myocardial infarction patients, the level of released plasminogen activator was lower in cases complicated with heart failure than in those without.
Localization (released) of plasminogen in heart associated with myocardial infarction
3) Confidence 0.13 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517077 Disease Relevance 0.87 Pain Relevance 0.18
In comparison with control subjects, a lower level of released plasminogen activator was found in all CHD patients, being especially marked in those with unstable angina pectoris and acute myocardial infarction.
Localization (released) of plasminogen associated with angina, coronary artery disease and myocardial infarction
4) Confidence 0.13 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517077 Disease Relevance 0.81 Pain Relevance 0.19
Relative to point 1, the utilization of plasminogen at point 2 was 24% and 17% in the on-pump and off-pump groups, respectively (p=0.001 both).
Localization (utilization) of plasminogen
5) Confidence 0.09 Published 2005 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15653441 Disease Relevance 0 Pain Relevance 0.09
Activated macrophages secrete a variety of neutral proteinases, including plasminogen activator.
Localization (secrete) of plasminogen in macrophages
6) Confidence 0.09 Published 1981 Journal J. Neurochem. Section Abstract Doc Link 6167674 Disease Relevance 0.35 Pain Relevance 0.33
Microglia cells are activated by the stimulation of ATP and releases plasminogen which is well known to promote the development of mesencephalic dopaminergic neurons and enhance neurite outgrowth from explants of neocortical tissue.
Localization (releases) of plasminogen in neurite
7) Confidence 0.06 Published 1998 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 10190130 Disease Relevance 0.17 Pain Relevance 0.34
and also triggers release of plasminogen [12, 17].
Localization (release) of plasminogen
8) Confidence 0.04 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.27 Pain Relevance 0.11
We have previously shown that ATP stimulates the release of plasminogen in a concentration-dependent manner from 10 to 100 µM with a peak response at 5–10 min after the stimulation [79].
Localization (release) of plasminogen
9) Confidence 0.04 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.07 Pain Relevance 0.90
ATP evoked the release of plasminogen [136] and IL-6 [135].
Localization (release) of plasminogen
10) Confidence 0.03 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.76 Pain Relevance 0.26

General Comments

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