INT253475

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.11
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fpr3) mitosis (Ncapg2) plasma membrane (Fpr3)
nucleus (Ncapg2) cell cycle (Ncapg2) cell division (Ncapg2)
Ncapg2 (Mus musculus)
Fpr3 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 32 98.52 Very High Very High Very High
Inflammation 24 90.32 High High
cOX1 4 72.96 Quite High
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 192 100.00 Very High Very High Very High
Infection 122 99.70 Very High Very High Very High
Sprains And Strains 20 94.56 High High
INFLAMMATION 28 90.32 High High
Death 40 76.08 Quite High
Necrosis 108 70.84 Quite High
Apoptosis 64 69.12 Quite High
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that infection with virulent Mtb induces the production of LXA4 in sufficient quantities to inhibit COX2 production, which represents an important manifestation of bacterial virulence.


Mtb Positive_regulation (induces) of Gene_expression (production) of LXA4 associated with mycobacterial infection, cox2 and infection
1) Confidence 0.21 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.49 Pain Relevance 0.31
Although it is tempting to advocate therapeutic targets of the lipoxin pathway for Mtb infection, further studies are required both to understand the mechanisms by which LXA4 production is activated via virulent Mtb and to determine the consequences of blocking the LXA4 production in the course of an infection of M?
Mtb Positive_regulation (activated) of Gene_expression (production) of LXA4 associated with mycobacterial infection and infection
2) Confidence 0.19 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.63 Pain Relevance 0.15

General Comments

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