INT253485

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.87
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fpr3, Ptger2) plasma membrane (Fpr3, Ptger2) signal transducer activity (Fpr3, Ptger2)
Fpr3 (Mus musculus)
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 32 98.04 Very High Very High Very High
Inflammation 24 5.00 Very Low Very Low Very Low
cOX1 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 108 99.56 Very High Very High Very High
Mycobacterial Infection 192 99.44 Very High Very High Very High
Infection 122 89.24 High High
Apoptosis 64 53.08 Quite High
Death 40 11.32 Low Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Sprains And Strains 20 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether induction of necrosis by LXA4 is based on an inhibitory effect of LXA4 on PGE2 synthesis, we determined whether LXA4 blocks synthesis of COX2, thus inhibiting generation of PGE2.
LXA4 Spec (whether) Regulation (effect) of Gene_expression (synthesis) of PGE2 associated with necrosis and cox2
1) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.32 Pain Relevance 0.09
, LXA4 acts by down-regulating PGE2 synthesis to induce necrosis.
LXA4 Regulation (regulating) of Gene_expression (synthesis) of PGE2 associated with necrosis
2) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.55 Pain Relevance 0.08

General Comments

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