INT25353

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 22
Total Number 25
Disease Relevance 18.51
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
cell adhesion (F8) plasma membrane (F8)
Anatomy Link Frequency
joint 1
muscles 1
skin 1
small intestine 1
F8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 91 98.38 Very High Very High Very High
pruritus 2 97.20 Very High Very High Very High
Pain 10 94.00 High High
anesthesia 2 85.88 High High
abdominal pain 4 79.44 Quite High
opiate 2 60.24 Quite High
analgesia 2 59.96 Quite High
Sciatica 1 57.76 Quite High
colic 1 47.52 Quite Low
imagery 3 29.60 Quite Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 726 100.00 Very High Very High Very High
Factor Viii Deficiency 21 99.32 Very High Very High Very High
Pressure And Volume Under Development 7 99.32 Very High Very High Very High
Hemarthrosis 46 99.20 Very High Very High Very High
Hematoma 23 98.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 87 98.92 Very High Very High Very High
Hemorrhage 361 98.74 Very High Very High Very High
Nose Bleeds 4 97.94 Very High Very High Very High
Infection 23 97.76 Very High Very High Very High
Pruritus 3 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The investigators concluded that most boys will have little bleeding and maintain good joint function on tailored prophylaxis with reduced FVIII consumption.
Negative_regulation (reduced) of FVIII in joint associated with hemorrhage
1) Confidence 0.59 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835555 Disease Relevance 0.39 Pain Relevance 0
Hemophilia A is a congenital bleeding disorder characterized by a deficiency of coagulation factor VIII.
Negative_regulation (deficiency) of factor VIII associated with coagulation disorder and factor viii deficiency
2) Confidence 0.49 Published 2006 Journal Surg. Today Section Abstract Doc Link 16715431 Disease Relevance 0.96 Pain Relevance 0.08
An APTT correction test suggested that decreased factor VIII activity was due to the presence of an inhibitor.
Negative_regulation (decreased) of factor VIII
3) Confidence 0.45 Published 2000 Journal Rinsho Byori Section Abstract Doc Link 11215417 Disease Relevance 0.24 Pain Relevance 0.07
Deficiency of factor VIII (FVIII) causes hemophilia A, the most common severe bleeding disorder in humans.
Negative_regulation (Deficiency) of factor VIII associated with coagulation disorder
4) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835555 Disease Relevance 0.53 Pain Relevance 0
Deficiency of factor VIII (FVIII) causes hemophilia A, the most common severe bleeding disorder in humans.
Negative_regulation (Deficiency) of FVIII associated with coagulation disorder
5) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835555 Disease Relevance 0.53 Pain Relevance 0
Thirteen patients had Factor VIII deficiency and two had Factor IX deficiency.
Negative_regulation (deficiency) of Factor VIII
6) Confidence 0.42 Published 1999 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 10101322 Disease Relevance 0.37 Pain Relevance 0
Activated prothrombin complex concentrate (FEIBA) treatment during surgery in patients with inhibitors to FVIII/IX.
Negative_regulation (inhibitors) of FVIII
7) Confidence 0.41 Published 2004 Journal Haemophilia Section Title Doc Link 14962207 Disease Relevance 0.39 Pain Relevance 0.12
Activated prothrombin complex concentrate (FEIBA) treatment during surgery in patients with inhibitors to FVIII/IX: the updated Norwegian experience.
Negative_regulation (inhibitors) of FVIII
8) Confidence 0.41 Published 2004 Journal Haemophilia Section Title Doc Link 15385045 Disease Relevance 0.38 Pain Relevance 0.12
More than 80% of patients with factor VIII autoantibodies bleed into the skin, muscles or soft tissues (including retroperitoneal hematoma) and mucous membranes (eg, epistaxis, gastrointestinal and urological bleeds), whereas hemarthroses, a typical manifestation of congenital factor VIII deficiency, are unusual.
Negative_regulation (deficiency) of factor VIII in muscles associated with hemarthrosis, nose bleeds and hematoma
9) Confidence 0.40 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2685275 Disease Relevance 1.15 Pain Relevance 0.09
Finally, another study investigated the effect of factor VIII and IX inhibitors on mortality in a hemophilia population (Darby 2004b).
Spec (investigated) Negative_regulation (inhibitors) of factor VIII associated with factor viii deficiency
10) Confidence 0.40 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2685275 Disease Relevance 1.78 Pain Relevance 0
Factor VIII inhibitors are distributed equally between sexes, although females predominate in the younger age group because of the association with pregnancy while males constitute the majority of patients with inhibitors over the age of 60 (Boggio and Green 2001).
Negative_regulation (inhibitors) of Factor VIII
11) Confidence 0.40 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2685275 Disease Relevance 0.72 Pain Relevance 0
The diagnosis of acquired hemophilia A was made based on the marked prolongation of activated partial thromboplastin time, an extremely low factor VIII activity, and a very high-titer factor VIII inhibitor.
Spec (partial) Negative_regulation (inhibitor) of factor VIII associated with coagulation disorder
12) Confidence 0.39 Published 2006 Journal Rinsho Ketsueki Section Abstract Doc Link 16715966 Disease Relevance 1.13 Pain Relevance 0.15
Eight non-serious AEs were considered at least possibly related to ADVATEĀ®: 2 mild AEs (lymphangitis and pruritus), 4 moderate AEs (one decreased hematocrit, one hemorrhage at time of drain removal, and 2 cases of edema at surgical site), and 2 severe (decreased coagulation FVIII coincident with a central venous access device-related infection and hematoma at surgical site).
Negative_regulation (decreased) of FVIII associated with pressure and volume under development, lymphangitis, hematoma, pruritus, cva and infection
13) Confidence 0.38 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291300 Disease Relevance 0.86 Pain Relevance 0.10
We report a case of a haemophiliac with a history of moderately high-titre FVIII inhibitor that had become undetectable.
Negative_regulation (inhibitor) of FVIII associated with coagulation disorder
14) Confidence 0.38 Published 2003 Journal Haemophilia Section Abstract Doc Link 12558792 Disease Relevance 0.81 Pain Relevance 0.07
Acquired hemophilia A is defined as the development of factor VIII inhibitors in a patient who was previously non-hemophilic.
Negative_regulation (inhibitors) of factor VIII associated with coagulation disorder
15) Confidence 0.37 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918632 Disease Relevance 0.45 Pain Relevance 0
Quantitative assays revealed a reduced level of factor VIII activity (1%) and the presence of a factor VIII inhibitor, measured at seven Bethesda units, in the serum.
Negative_regulation (reduced) of factor VIII
16) Confidence 0.37 Published 2010 Journal J Med Case Reports Section Abstract Doc Link PMC2918632 Disease Relevance 1.01 Pain Relevance 0.04
Quantitative assays revealed a reduced level of factor VIII activity (1%) and the presence of a factor VIII inhibitor, measured at seven Bethesda units, in the serum.
Negative_regulation (inhibitor) of factor VIII
17) Confidence 0.37 Published 2010 Journal J Med Case Reports Section Abstract Doc Link PMC2918632 Disease Relevance 1.00 Pain Relevance 0.04
A high risk of AIDS has been reported among patients with hemophilia who received lyophilized commercial factor VIII and IX concentrates of American origin.
Negative_regulation (received) of factor VIII associated with coagulation disorder and acquired immune deficiency syndrome or hiv infection
18) Confidence 0.36 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517721 Disease Relevance 1.28 Pain Relevance 0.09
Recurrent intramural hematoma of the small intestine in a severe hemophilia A patient with a high titer of factor VIII inhibitor: a case report and review of the literature.
Negative_regulation (inhibitor) of factor VIII in small intestine associated with coagulation disorder and hematoma
19) Confidence 0.36 Published 2006 Journal Int. J. Hematol. Section Title Doc Link 16926140 Disease Relevance 0.64 Pain Relevance 0.09
We report here 2 cases of acquired factor VIII inhibitor and 1 case of factor V inhibitor.
Negative_regulation (inhibitor) of factor VIII
20) Confidence 0.33 Published 2000 Journal Rinsho Byori Section Abstract Doc Link 11215417 Disease Relevance 0.16 Pain Relevance 0

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