INT253540

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.43
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
lipid metabolic process (Lpl)
Anatomy Link Frequency
muscle 3
liver 1
Lpl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 30 95.36 Very High Very High Very High
agonist 18 85.92 High High
alcohol 6 78.92 Quite High
Inflammation 44 50.00 Quite Low
Inflammatory response 18 6.40 Low Low
Kinase C 12 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 22 96.48 Very High Very High Very High
Hepatocellular Cancer 10 86.76 High High
Hepatitis C Virus Infection 2 84.00 Quite High
Hepatitis 4 83.48 Quite High
Liver Disease 12 79.48 Quite High
Death 2 64.32 Quite High
Hepatomegaly 6 62.76 Quite High
INFLAMMATION 62 50.00 Quite Low
Cancer 14 50.00 Quite Low
Hypolipidemia 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphoinositide-3-kinase (PI3K) pathway is also involved in the regulation of LPL gene transcription through Sp1/Sp3
Positive_regulation (through) of Transcription (transcription) of LPL gene
1) Confidence 0.29 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
on LPL gene transcription is not mediated at the level of Sp1/Sp3 DNA binding
Neg (not) Positive_regulation (mediated) of Transcription (transcription) of LPL gene
2) Confidence 0.27 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
upregulates lipoprotein lipase transcription in liver and muscle and this leads to increased TG hydrolysis.
Positive_regulation (upregulates) of Transcription (transcription) of lipoprotein lipase in muscle
3) Confidence 0.09 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.71 Pain Relevance 0.12
upregulates lipoprotein lipase transcription in liver and muscle and this leads to increased TG hydrolysis.
Positive_regulation (upregulates) of in liver Transcription (transcription) of lipoprotein lipase in muscle
4) Confidence 0.03 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.71 Pain Relevance 0.12

General Comments

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