INT253542

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.16
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp1) intracellular (Sp1) DNA binding (Sp1)
transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 39 66.04 Quite High
Inflammation 12 65.64 Quite High
IPN 3 49.60 Quite Low
Pain 3 46.64 Quite Low
Inflammatory response 9 43.96 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 33 90.24 High High
Disorder Of Lipid Metabolism 6 70.48 Quite High
Disease 9 66.00 Quite High
INFLAMMATION 21 65.64 Quite High
Renal Disease 3 51.84 Quite High
Inflammatory Pain 3 49.60 Quite Low
Pain 3 46.64 Quite Low
Obesity 6 12.72 Low Low
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional inhibition that is potentially mediated by a CK2-mediated phosphorylation of Sp1 has also been suggested for the flow-dependent suppression of endothelial Toll-like receptor 2 expression [34].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of Sp1
1) Confidence 0.27 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.37 Pain Relevance 0.06
mediated via phosphorylation of Sp1 (and possibly Sp3), which leads to decreased binding to regulatory sequences in the LPL gene.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of Sp1
2) Confidence 0.27 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.37 Pain Relevance 0.09
Indeed, CK2-mediated phosphorylation of the carboxyl terminus of Sp1 is associated with a decrease in its DNA binding activity [35].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of Sp1
3) Confidence 0.25 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.41 Pain Relevance 0.05

General Comments

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