INT253558

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 1.09
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp3) intracellular (Sp3) DNA binding (Sp3)
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 117 99.98 Very High Very High Very High
Inflammatory response 27 80.52 Quite High
Pain 9 46.88 Quite Low
IPN 9 42.00 Quite Low
Inflammation 36 32.88 Quite Low
Disease Link Frequency Relevance Heat
Obesity 18 91.44 High High
Atherosclerosis 99 83.08 Quite High
INFLAMMATION 63 80.16 Quite High
Disease 27 79.04 Quite High
Diabetes Mellitus 9 78.92 Quite High
Disorder Of Lipid Metabolism 18 77.08 Quite High
Cancer 9 52.16 Quite High
Necrosis 9 51.60 Quite High
Pain 9 46.88 Quite Low
Inflammatory Pain 9 42.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-mediated suppression of Sp1/Sp3 binding (Fig. 7C).
Negative_regulation (suppression) of Sp1/Sp3 Binding (binding) of
1) Confidence 0.39 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.03
-mediated decrease in Sp1/Sp3 binding was analysed by EMSA.
Negative_regulation (decrease) of Sp1/Sp3 Spec (analysed) Binding (binding) of
2) Confidence 0.39 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
-mediated reduction in Sp1/Sp3 binding.
Negative_regulation (reduction) of Sp1/Sp3 Binding (binding) of
3) Confidence 0.39 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.40 Pain Relevance 0.05
As shown in Fig. 7D, rapamycin attenuated the decrease in Sp1/Sp3 binding.


Negative_regulation (decrease) of Sp1/Sp3 Binding (binding) of
4) Confidence 0.29 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
whereby the cytokine decreases the binding of Sp1 and Sp3 to three conserved recognition sequences in the regulatory region of the LPL gene [9].
Negative_regulation (decreases) of Sp3 Binding (binding) of associated with cytokine
5) Confidence 0.29 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.47 Pain Relevance 0.05
-mediated decrease in Sp1/Sp3 binding to regulatory sequences in the gene [9].
Negative_regulation (decrease) of Sp1/Sp3 Binding (binding) of
6) Confidence 0.29 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.22 Pain Relevance 0.14
-mediated downregulation of murine growth hormone receptor expression has been shown to be due to inhibition of Sp1 and Sp3 binding [30].
Negative_regulation (inhibition) of Sp3 Binding (binding) of
7) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.06
Phosphorylation of extracts from untreated cells with two different concentrations of CK2 reduced the binding of Sp1/Sp3 to levels observed in IFN-?
Negative_regulation (reduced) of Sp1/Sp3 Binding (binding) of
8) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
is mediated through decreased binding of Sp1 and Sp3 [29].
Negative_regulation (decreased) of Sp3 Binding (binding) of
9) Confidence 0.28 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04

General Comments

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