INT25356

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 23
Disease Relevance 17.62
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (S100A12) extracellular region (S100A12) nucleus (S100A12)
cytoplasm (S100A12)
Anatomy Link Frequency
muscle 2
coronary artery 1
spindle cells 1
aorta 1
neuron 1
S100A12 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 211 100.00 Very High Very High Very High
Somatostatin 2 99.80 Very High Very High Very High
spastic colon 144 98.76 Very High Very High Very High
Inflammation 203 96.72 Very High Very High Very High
imagery 24 89.60 High High
Acupuncture 50 86.52 High High
cva 2 85.32 High High
headache 10 83.92 Quite High
fifth nerve 1 81.04 Quite High
Pain 17 77.16 Quite High
Disease Link Frequency Relevance Heat
Disease 530 100.00 Very High Very High Very High
Nicotine Addiction 81 100.00 Very High Very High Very High
Malaria 210 99.56 Very High Very High Very High
Cancer 123 99.50 Very High Very High Very High
Inflammatory Bowel Disease 498 99.44 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

126 98.76 Very High Very High Very High
Necrosis 6 98.68 Very High Very High Very High
Glioma 1 98.48 Very High Very High Very High
Vomiting 11 97.92 Very High Very High Very High
Liposarcoma 45 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown above, the levels of S100A12 in serum of current smokers, diagnosed with CD appeared to be elevated, compared to CD non-smokers.
Positive_regulation (elevated) of S100A12 associated with nicotine addiction and crohn's disease
1) Confidence 0.69 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.94 Pain Relevance 0.34
In conclusion, it is evident that the upregulation of S100A12 is not confined to the boundaries of an IBD-occupied intestine but is also reflected systemically and subsequently detected in serum.
Positive_regulation (upregulation) of S100A12 in intestine associated with inflammatory bowel disease
2) Confidence 0.69 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.26 Pain Relevance 0.04
This increase in serum S100A12 is associated with IBD and is also well correlated with the "classic" markers of inflammation CRP and SAA.
Positive_regulation (increase) of S100A12 associated with inflammatory bowel disease and inflammation
3) Confidence 0.69 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.35 Pain Relevance 0.05
In our study, a significant elevation in serum S100A12 levels correlated well with IBD but not with IBS, thus allowing the distinction between the two entities.
Positive_regulation (elevation) of S100A12 associated with inflammatory bowel disease and spastic colon
4) Confidence 0.69 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.85 Pain Relevance 0.37
In the UC group, the levels of serum S100A12 seemed to be higher in non-smokers than in those found in current smokers.
Positive_regulation (higher) of S100A12 associated with inflammatory bowel disease and nicotine addiction
5) Confidence 0.50 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.81 Pain Relevance 0.33
Immunohistochemical staining was positive for S-100 protein but negative for epithelial membrane antigen.
Positive_regulation (positive) of S-100 protein
6) Confidence 0.50 Published 2004 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 15686179 Disease Relevance 1.24 Pain Relevance 0.15
However, pairwise comparisons of signal values showed upregulation of several S100 calcium binding proteins; S100A8 (calgranulin A), S100A12 (calgranulin C), and S100P during active phase of the disease compared to remission.
Positive_regulation (upregulation) of S100A12
7) Confidence 0.49 Published 2006 Journal Headache Section Body Doc Link 17115985 Disease Relevance 0 Pain Relevance 0
Increased levels of circulating S100A12 are found in IBD, compared to IBS.
Positive_regulation (Increased) of S100A12 associated with inflammatory bowel disease and spastic colon
8) Confidence 0.46 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2964606 Disease Relevance 1.21 Pain Relevance 0.72
Immunohistochemically, the spindle cells were focally positive for factor VIII-associated antigen and vimentin, and negative for S-100 protein, desmin, and epithelial membrane antigen.
Positive_regulation (negative) of S-100 protein in spindle cells
9) Confidence 0.45 Published 1995 Journal J. Korean Med. Sci. Section Abstract Doc Link 8527049 Disease Relevance 0.65 Pain Relevance 0.15
Somatostatin-producing cells and S-100 protein-containing cells were usually also present as two distinct cell populations, but positive staining for both S-100 protein and somatostatin was occasionally observed within the same cells.
Positive_regulation (staining) of S-100 protein associated with somatostatin
10) Confidence 0.45 Published 1989 Journal Acta Morphol Hung Section Abstract Doc Link 2518343 Disease Relevance 0.14 Pain Relevance 0.17
Significant increase in serum S-100 beta protein was also observed even before cardiopulmonary bypass in cardiopulmonary bypass patients, or before manipulation of the heart and aorta in off-pump patients.
Positive_regulation (increase) of serum S-100 beta protein in aorta
11) Confidence 0.39 Published 2005 Journal Ann. Thorac. Surg. Section Body Doc Link 16181873 Disease Relevance 0 Pain Relevance 0
Several studies suggest that stimulation of P6 is also effective in treating chemotherapy-induced nausea [43].
Positive_regulation (stimulation) of P6 associated with vomiting
12) Confidence 0.32 Published 2001 Journal BMC Complement Altern Med Section Body Doc Link PMC37539 Disease Relevance 0.96 Pain Relevance 0.45
METHODS: We conducted a prospective, longitudinal study to evaluate serum S-100 beta protein, an early marker of brain injury, in patients electively undergoing off-pump (n = 30) or traditional coronary artery bypass graft (n = 60).
Positive_regulation (evaluate) of serum S-100 beta protein in coronary artery
13) Confidence 0.28 Published 2005 Journal Ann. Thorac. Surg. Section Body Doc Link 16181873 Disease Relevance 0 Pain Relevance 0
Immunohistochemically, the tumor cells were positive for alpha-smooth muscle actin and muscle actin, and negative for KIT, CD34, and S-100 protein.
Positive_regulation (negative) of S-100 protein in muscle associated with cancer
14) Confidence 0.28 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 17460456 Disease Relevance 1.12 Pain Relevance 0.07
RESULTS: Serum S-100 beta protein was lowest immediately before induction of anesthesia and significantly increased before and after cardiopulmonary bypass, then declined by the first postoperative day in both groups.
Positive_regulation (increased) of Serum S-100 beta protein
15) Confidence 0.26 Published 2005 Journal Ann. Thorac. Surg. Section Body Doc Link 16181873 Disease Relevance 0 Pain Relevance 0
The cells presented positive for GFAP, S-100 protein, vimentin, Nestin and neurofilament, and dotlike positive for epithelial membrane antigen, but negative for Syn and NeuN.
Positive_regulation (positive) of S-100 protein
16) Confidence 0.25 Published 2008 Journal Neuropathology Section Abstract Doc Link 18312548 Disease Relevance 0.76 Pain Relevance 0.08
Immunohistochemical staining was negative for CD117 and positive for S-100 protein.
Positive_regulation (positive) of S-100 protein
17) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887402 Disease Relevance 0.92 Pain Relevance 0.08
S100A12 is an IL-1 and TNF-inducible mediator found to be increased in severe malaria serum (M.
Positive_regulation (increased) of S100A12 associated with malaria
18) Confidence 0.16 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.50 Pain Relevance 0.04
The granular cells of the current case were positive for neuron-specific enolase (NSE), S-100 protein, GFAP, vimentin, CD 68, lysozyme, and alpha-1-antitrypsin.
Positive_regulation (positive) of S-100 protein in neuron
19) Confidence 0.14 Published 2008 Journal Neuropathology Section Abstract Doc Link 18466222 Disease Relevance 0.88 Pain Relevance 0.08
In all 7 lesions examined immunohistochemically, the tumor cells stained intensely positive for vimentin, S-100 protein, EMA, CAM5.2, AE1/AE3, and CK18 (Fig. 5d,e).
Positive_regulation (positive) of S-100 protein associated with cancer
20) Confidence 0.13 Published 2008 Journal Skeletal Radiol Section Body Doc Link PMC2257990 Disease Relevance 0.62 Pain Relevance 0

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