INT253568

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.37
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) nucleus (Sp3)
intracellular (Sp3) plasma membrane (Lpl) DNA binding (Sp3)
Lpl (Mus musculus)
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 52 99.80 Very High Very High Very High
Inflammation 16 63.64 Quite High
IPN 4 47.60 Quite Low
Pain 4 44.64 Quite Low
Inflammatory response 12 41.96 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 44 88.24 High High
INFLAMMATION 28 63.64 Quite High
Disease 12 53.60 Quite High
Renal Disease 4 49.84 Quite Low
Disorder Of Lipid Metabolism 8 48.16 Quite Low
Inflammatory Pain 4 47.60 Quite Low
Pain 4 44.64 Quite Low
Cytomegalovirus Infection 8 18.92 Low Low
Obesity 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-mediated reduction of Sp1/Sp3 binding to the LPL gene.
Negative_regulation (reduction) of LPL gene Binding (binding) of Sp1/Sp3
1) Confidence 0.19 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
To determine whether the PI3K pathway was also involved in the cytokine-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene, the effect of pre-treatment of the cells with three different concentrations of the PI3K inhibitor LY294002 on the IFN-?
Negative_regulation (reduction) of LPL gene Binding (binding) of Sp1/Sp3 associated with cytokine
2) Confidence 0.19 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene could be attenuated by incubation of the cells with 10 µM and 40 µM of the CK2 inhibitor apigenin [9,16–19].
Negative_regulation (reduction) of LPL gene Binding (binding) of Sp1/Sp3
3) Confidence 0.19 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
mediated via phosphorylation of Sp1 (and possibly Sp3), which leads to decreased binding to regulatory sequences in the LPL gene.
Negative_regulation (decreased) of LPL gene Binding (binding) of Sp3
4) Confidence 0.17 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.37 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox