INT253572

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Csnk2a2, Sp1) intracellular (Sp1) DNA binding (Sp1)
cell cycle (Csnk2a2) transcription factor binding (Sp1) kinase activity (Csnk2a2)
Csnk2a2 (Mus musculus)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 65 76.88 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
Inflammatory response 15 5.00 Very Low Very Low Very Low
IPN 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 55 5.00 Very Low Very Low Very Low
INFLAMMATION 35 5.00 Very Low Very Low Very Low
Disease 15 5.00 Very Low Very Low Very Low
Obesity 10 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 10 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 10 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Diabetes Mellitus 5 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low
Renal Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fig. 3A shows that Sp1 interacted with both the catalytic subunits of CK2 and that this association was increased in cells treated with IFN-?.
CK2 Binding (interacted) of Sp1
1) Confidence 0.17 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
Our subsequent studies focused on the interaction and action of CK2 on Sp1 because preliminary co-transfection assays showed that Sp1, but not Sp3, was the main activator of the LPL promoter (data not shown).
CK2 Binding (interaction) of Sp1
2) Confidence 0.13 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
We investigated the interaction of CK2 subunits with Sp1 by co-immunoprecipitation assays.
CK2 Binding (interaction) of Sp1
3) Confidence 0.13 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.03
CK2 associates with, and phosphorylates, Sp1
CK2 Binding (associates) of Sp1
4) Confidence 0.13 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
CK2-mediated phosphorylation of Sp1 is associated with decreased DNA binding
CK2 Binding (associated) of Sp1
5) Confidence 0.13 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0

General Comments

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