INT253576

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.85
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) nucleus (Sp3)
intracellular (Sp3) plasma membrane (Lpl) DNA binding (Sp3)
Lpl (Mus musculus)
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 78 99.70 Very High Very High Very High
Inflammation 24 63.64 Quite High
IPN 6 47.60 Quite Low
Pain 6 44.64 Quite Low
Inflammatory response 18 41.96 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 66 88.24 High High
Obesity 12 78.84 Quite High
Diabetes Mellitus 6 78.36 Quite High
Disorder Of Lipid Metabolism 12 70.48 Quite High
INFLAMMATION 42 63.64 Quite High
Cancer 6 58.72 Quite High
Necrosis 6 58.16 Quite High
Disease 18 53.60 Quite High
Renal Disease 6 49.84 Quite Low
Inflammatory Pain 6 47.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because this synergism was mediated at the level of gene transcription [28], we wondered whether this occurred at the level of Sp1/Sp3 binding to the LPL gene.
LPL gene Binding (binding) of Sp1/Sp3
1) Confidence 0.22 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04
mediated via phosphorylation of Sp1 (and possibly Sp3), which leads to decreased binding to regulatory sequences in the LPL gene.
LPL gene Binding (binding) of Sp3
2) Confidence 0.19 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.37 Pain Relevance 0.09
-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene could be attenuated by incubation of the cells with 10 µM and 40 µM of the CK2 inhibitor apigenin [9,16–19].
LPL gene Binding (binding) of Sp1/Sp3
3) Confidence 0.17 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
To determine whether the PI3K pathway was also involved in the cytokine-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene, the effect of pre-treatment of the cells with three different concentrations of the PI3K inhibitor LY294002 on the IFN-?
LPL gene Binding (binding) of Sp1/Sp3 associated with cytokine
4) Confidence 0.16 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
whereby the cytokine decreases the binding of Sp1 and Sp3 to three conserved recognition sequences in the regulatory region of the LPL gene [9].
LPL gene Binding (binding) of Sp3 associated with cytokine
5) Confidence 0.16 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.48 Pain Relevance 0.05
-mediated reduction of Sp1/Sp3 binding to the LPL gene.
LPL gene Binding (binding) of Sp1/Sp3
6) Confidence 0.16 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04

General Comments

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