INT253577

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Csnk2a2, Sp1) intracellular (Sp1) DNA binding (Sp1)
cell cycle (Csnk2a2) transcription factor binding (Sp1) kinase activity (Csnk2a2)
Csnk2a2 (Mus musculus)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 26 58.40 Quite High
Inflammation 8 58.00 Quite High
IPN 2 41.96 Quite Low
Pain 2 39.00 Quite Low
Inflammatory response 6 36.32 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 22 82.60 Quite High
INFLAMMATION 14 58.00 Quite High
Disorder Of Lipid Metabolism 4 56.00 Quite High
Disease 6 51.52 Quite High
Renal Disease 2 44.20 Quite Low
Inflammatory Pain 2 41.96 Quite Low
Pain 2 39.00 Quite Low
Obesity 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional inhibition that is potentially mediated by a CK2-mediated phosphorylation of Sp1 has also been suggested for the flow-dependent suppression of endothelial Toll-like receptor 2 expression [34].
CK2 Positive_regulation (mediated) of Phosphorylation (phosphorylation) of Sp1
1) Confidence 0.17 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.37 Pain Relevance 0.06
CK2-mediated phosphorylation of Sp1 is associated with decreased DNA binding
CK2 Positive_regulation (mediated) of Phosphorylation (phosphorylation) of Sp1
2) Confidence 0.17 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0

General Comments

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