INT253595

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Anatomy Link Frequency
neurons 1
Abca1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 14 57.96 Quite High
Hippocampus 10 34.48 Quite Low
Thalamus 1 32.24 Quite Low
Inflammation 19 5.00 Very Low Very Low Very Low
Kinase C 18 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
diabetic neuropathy 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 8 97.92 Very High Very High Very High
Viral Meningitis 9 71.72 Quite High
Infection 8 62.36 Quite High
Dementia 15 50.00 Quite Low
Disease 100 29.56 Quite Low
Heart Disease 3 29.28 Quite Low
Increased Venous Pressure Under Development 20 28.68 Quite Low
Congenital Anomalies 6 25.52 Quite Low
Diabetes Mellitus 50 5.00 Very Low Very Low Very Low
INFLAMMATION 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After cholesterol is synthesised in astrocytes, it is released through ABCA1 and packaged into lipoprotein particles resembling HDL, which in turn are then taken up into neurons through the recognition of ApoE by a variety of lipoprotein receptors such as LDLR, LRP and the ApoE receptor.
Localization (released) of ABCA1 in neurons associated with disorder of lipid metabolism
1) Confidence 0.37 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.15 Pain Relevance 0.03
Non-structural
       proteins perform functions like actin binding, zinc-binding, calcium-binding, hydrolases, Carbon-Oxygen Lyases, P-type ATPase, proteins belonging to major facilitator family (MFS), secreting main terminal branch (MTB) 
       family, phosphotransfer-driven group translocators and ATP-binding cassette (ABC) family group of proteins. 
Localization (secreting) of ATP-binding cassette
2) Confidence 0.10 Published 2008 Journal Bioinformation Section Abstract Doc Link PMC2586131 Disease Relevance 0.20 Pain Relevance 0

General Comments

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