INT253625

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HNRNPA1) transport (HNRNPA1) mRNA processing (HNRNPA1)
nucleolus (HNRNPA1) RNA binding (HNRNPA1) nucleus (HNRNPA1)
Anatomy Link Frequency
neurons 1
HNRNPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 7 62.64 Quite High
cytokine 11 59.36 Quite High
Inflammation 5 39.56 Quite Low
Inflammatory response 2 22.08 Low Low
Neurobehavioral 7 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 189 100.00 Very High Very High Very High
Injury 11 91.40 High High
Viral Meningitis 11 72.20 Quite High
Drug Induced Neurotoxicity 12 52.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 73 50.00 Quite Low
INFLAMMATION 7 39.56 Quite Low
Sprains And Strains 11 38.40 Quite Low
Infection 42 32.32 Quite Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HCV core protein exposure was not toxic to astrocytes (Figure 4A) while the highest concentration of HCV core protein (100 nM) was cytotoxic to neurons, indicated by the loss of ?
Localization (concentration) of core protein in neurons associated with hepatitis c virus infection
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.06 Pain Relevance 0.06
Experiments have shown that core protein is released from ER membrane, bind to genomic RNA and form
Localization (released) of core protein
2) Confidence 0.01 Published 2008 Journal Bioinformation Section Body Doc Link PMC2586131 Disease Relevance 0.07 Pain Relevance 0

General Comments

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