INT25363

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 144
Total Number 149
Disease Relevance 64.78
Pain Relevance 75.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 15
sensory neurons 5
bladder 3
DRGs 3
myometrium 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 2164 100.00 Very High Very High Very High
antagonist 1033 100.00 Very High Very High Very High
agonist 707 100.00 Very High Very High Very High
dorsal root ganglion 691 100.00 Very High Very High Very High
Calcitonin gene-related peptide 156 100.00 Very High Very High Very High
Somatostatin 6 100.00 Very High Very High Very High
member 8 6 100.00 Very High Very High Very High
vanilloid receptor subtype 1 2 100.00 Very High Very High Very High
nociceptor 905 99.98 Very High Very High Very High
Inflammation 1006 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cold Sores 952 100.00 Very High Very High Very High
Ganglion Cysts 950 100.00 Very High Very High Very High
Hypomagnesemia 3 100.00 Very High Very High Very High
INFLAMMATION 1062 99.96 Very High Very High Very High
Targeted Disruption 694 99.96 Very High Very High Very High
Diabetes Mellitus 309 99.96 Very High Very High Very High
Nociception 735 99.84 Very High Very High Very High
Overactive Bladder 132 99.82 Very High Very High Very High
Hyperalgesia 787 99.76 Very High Very High Very High
Pain 1949 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of shRNAs targeting TRPV1 in transgenic (tg) mice was proven by RNase protection assays, and TRPV1 downregulation was confirmed by reduced expression of TRPV1 mRNA and lack of receptor agonist binding in spinal cord membranes.
Negative_regulation (downregulation) of TRPV1 in spinal cord associated with targeted disruption, agonist and spinal cord
1) Confidence 0.59 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249134 Disease Relevance 0.66 Pain Relevance 0.30
These results demonstrate that capsazepine affords neuroprotection through inhibition of I(h) rather than inhibition of VR1.
Negative_regulation (inhibition) of VR1
2) Confidence 0.59 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14602831 Disease Relevance 0.42 Pain Relevance 0.12
However, capsazepine was still neuroprotective in slices prepared from VR1 knock-out mice, which exhibited the same degree of neurodegeneration to that observed in slices prepared from wild-type mice, excluding the possibility that it afforded neuroprotection through inhibition of VR1.
Negative_regulation (inhibition) of VR1 associated with targeted disruption
3) Confidence 0.59 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14602831 Disease Relevance 0.60 Pain Relevance 0.19
Pharmacological blockade of TRPV1 represents a new strategy in pain relief.
Negative_regulation (blockade) of TRPV1 associated with pain
4) Confidence 0.59 Published 2006 Journal Trends Mol Med Section Abstract Doc Link 16996800 Disease Relevance 0.87 Pain Relevance 1.08
Nociceptors lacking TRPV1 and TRPV2 have normal heat responses.
Negative_regulation (lacking) of TRPV1 in Nociceptors associated with nociceptor
5) Confidence 0.59 Published 2004 Journal J. Neurosci. Section Title Doc Link 15254097 Disease Relevance 0.09 Pain Relevance 0.46
We found that disruption of the calmodulin binding segment prevented TRPV1 desensitization even in the presence of extracellular Ca2+.
Negative_regulation (desensitization) of TRPV1
6) Confidence 0.59 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469041 Disease Relevance 0.17 Pain Relevance 0.40
Third, at concentrations needed to inhibit TRPV1 (~10 ?
Negative_regulation (inhibit) of TRPV1
7) Confidence 0.58 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0 Pain Relevance 0.51
Intravesical administration of capsaicin and RTX, a potent TRPV1 agonist results in a marked decrease in TRPV1, SP and CGRP immunoreactivity in the rat urinary bladder [13, 14], which may be as a result of nerve terminal degeneration mediated by these agents [27, 35, 37, 40, 146, 163].
Negative_regulation (decrease) of TRPV1 in nerve associated with calcitonin gene related peptide, qutenza, agonist and substance p
8) Confidence 0.58 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.74 Pain Relevance 0.69
During regular adipogenesis TRPV1 channels were downregulated which was accompanied by a significant and time-dependent reduction of calcium influx.
Negative_regulation (downregulated) of TRPV1
9) Confidence 0.58 Published 2007 Journal Circ. Res. Section Abstract Doc Link 17347480 Disease Relevance 0.92 Pain Relevance 0.47
Importantly, inhibition of TRPV1 by an intracerebroventricular injection of capsazepine abolished the antinociceptive effect of orally administered acetaminophen, supporting the view that acetaminophen has a central site of action [10], [27].
Negative_regulation (inhibition) of TRPV1 associated with paracetamol, antinociceptive and intracerebroventricular
10) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941447 Disease Relevance 0.29 Pain Relevance 1.45
Our results demonstrate a significant reduction in Trpv1 mRNA levels in sensory neurons from mice injected with the vector expressing shTRPV1 and 59% reduction in TrpV1 protein levels following injection of the vector expressing miR-TRPV1.
Negative_regulation (reduction) of TrpV1 protein in sensory neurons
11) Confidence 0.56 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 0.82 Pain Relevance 0.34
Trpv1 mRNA in these animals was reduced by 53.6 ± 11.2% (P = 0.01) (n = 4, mean ± SD).
Negative_regulation (reduced) of Trpv1
12) Confidence 0.56 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.16 Pain Relevance 0.28
In the DRGs of the OSM-deficient mice, vanilloid receptor 1 (VR1)- and P2X3-positive small-sized neurons were significantly decreased.
Negative_regulation (decreased) of vanilloid receptor 1 in DRGs
13) Confidence 0.56 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14985435 Disease Relevance 0.07 Pain Relevance 0.12
Apoptosis was completely prevented by inhibiting TRPV1 receptors with capsazepine or by removing extracellular calcium or in sensory neurons from TRPV1(-/-) mice.
Negative_regulation (inhibiting) of TRPV1 in sensory neurons associated with apoptosis
14) Confidence 0.55 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 14633515 Disease Relevance 0.89 Pain Relevance 0
Specific inhibition of EGFR and TRPV1 indicated that capsaicin-induced ERK activation in A431 cells was dependent on EGFR, but not TRPV1.
Negative_regulation (inhibition) of TRPV1 in A431 associated with qutenza
15) Confidence 0.52 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20660715 Disease Relevance 0.78 Pain Relevance 0.78
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.
Negative_regulation (blockade) of TRPV1 associated with cancer pain, qutenza, analgesic and bone cancer
16) Confidence 0.51 Published 2005 Journal J. Neurosci. Section Title Doc Link 15788769 Disease Relevance 0.90 Pain Relevance 1.32
In OSM-deficient mice, TRPV1/P2X3/OSMRbeta triple-positive neurons were significantly decreased.
Negative_regulation (decreased) of TRPV1 in neurons
17) Confidence 0.51 Published 2005 Journal Anat Sci Int Section Abstract Doc Link 15794131 Disease Relevance 0.13 Pain Relevance 0.22
Methylation of the amide group decreased the activity at VR1, AMT, and FAAH.
Negative_regulation (decreased) of VR1
18) Confidence 0.50 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861807 Disease Relevance 0 Pain Relevance 0.27
On the aromatic ring, the substitution of the 3-methoxy group with a chlorine atom or the lack of the 4-hydroxy group decreased the activity on VR1 and AMT, but not the affinity for CB1 receptors, and increased the capability to inhibit FAAH.
Negative_regulation (decreased) of VR1
19) Confidence 0.50 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861807 Disease Relevance 0 Pain Relevance 0.25
The mRNA levels for the putative mechanosensitive ion channels ASIC2a and 2b are increased, whereas transcript levels for the heat receptor TRPV1 are decreased.
Negative_regulation (decreased) of TRPV1
20) Confidence 0.46 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.27

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