INT253749

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hspa1a) response to stress (Hspa1a) cytoplasm (Hspa1a)
Hspa1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 2 71.12 Quite High
Inflammatory mediators 15 60.68 Quite High
Inflammatory response 27 56.40 Quite High
Inflammation 39 5.00 Very Low Very Low Very Low
cytokine 24 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 94 100.00 Very High Very High Very High
Insulin Resistance 25 73.92 Quite High
INFLAMMATION 86 71.12 Quite High
Targeted Disruption 2 68.36 Quite High
Sepsis 99 54.68 Quite High
Diabetes Mellitus 11 40.64 Quite Low
Apoptosis 11 33.52 Quite Low
Stress 1 28.04 Quite Low
Critical Illness 1 22.76 Low Low
Toxicity 1 9.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Knockdown of Hsp72 by siRNA in these cells reduced the effect of HS+MES (Fig. 9F), suggesting that the effect of HS+MES is partly mediated by Hsp72.
Negative_regulation (Knockdown) of Hsp72 associated with shock
1) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.86 Pain Relevance 0
Recently, a number of structurally diverse, multifunctional, ubiquitous host proteins
         – such as HMGB1 and heat shock protein 72 (HSP72) – have been
         categorised as ‘alarmins’ based on the following shared properties
         (Ref. 50) (Fig.
           2). 
Negative_regulation (number) of HSP72 associated with shock
2) Confidence 0.10 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.39 Pain Relevance 0.09

General Comments

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