INT253750

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.43
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Apex1) mitochondrion (Apex1) lyase activity (Apex1)
aging (Apex1) endoplasmic reticulum (Apex1) intracellular (Apex1)
Anatomy Link Frequency
macrophage 2
Apex1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 72 100.00 Very High Very High Very High
cytokine 46 100.00 Very High Very High Very High
chemokine 10 100.00 Very High Very High Very High
Inflammatory mediators 30 83.20 Quite High
Inflammatory response 54 77.76 Quite High
Nicotine 2 69.36 Quite High
agonist 2 69.00 Quite High
vagus nerve 12 63.76 Quite High
Neuropeptide 6 7.96 Low Low
cINOD 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 166 100.00 Very High Very High Very High
Sepsis 198 96.96 Very High Very High Very High
Infection 36 92.08 High High
Injury 28 91.04 High High
Disease 28 62.16 Quite High
Apoptosis 22 49.60 Quite Low
Death 4 27.76 Quite Low
Adult Respiratory Distress Syndrome 8 25.08 Quite Low
Lifespan 2 21.48 Low Low
Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Engagement of various TLRs by specific PAMPs leads to production and release of cytokines
         (such as TNF and the interleukins IL- 1 and IL-6) and chemokines (such as IL-8, and the
         ‘macrophage inflammatory proteins’ CCL3 and CCL4) (Ref. 12). 
Positive_regulation (leads) of Gene_expression (production) of Ref in macrophage associated with chemokine, inflammation and cytokine
1) Confidence 0.10 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.07 Pain Relevance 0.49
Indeed, administration of
         stearoyl LPC significantly attenuated circulating HMGB1 levels (Ref. 47), indicating that stearoyl LPC protects against experimental
         sepsis partly by facilitating elimination of invading pathogens and partly by attenuating
         systemic HMGB1 accumulation (Ref. 130).


Positive_regulation (circulating) of Gene_expression (levels) of Ref associated with sepsis
2) Confidence 0.09 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.36 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox