INT253751

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.94
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lif) extracellular region (Lif)
Anatomy Link Frequency
chondrocytes 1
immune cells 1
Lif (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 15 100.00 Very High Very High Very High
cytokine 139 99.88 Very High Very High Very High
rheumatoid arthritis 85 98.76 Very High Very High Very High
Inflammation 45 95.64 Very High Very High Very High
Arthritis 6 94.40 High High
Inflammatory response 39 78.60 Quite High
visual analogue scale 12 77.80 Quite High
Pain 13 76.72 Quite High
cva 14 45.20 Quite Low
vagus nerve 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 104 100.00 Very High Very High Very High
Leukemia 5 100.00 Very High Very High Very High
Rheumatoid Arthritis 87 98.76 Very High Very High Very High
Disease 76 94.96 High High
Arthritis 2 94.40 High High
Infection 18 88.92 High High
Sepsis 99 87.56 High High
Coagulation Disorder 46 87.04 High High
Arthropathy 20 81.44 Quite High
Hemarthrosis 14 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In most countries of the developing world, such therapy is impractical, and even the reduced expense of p/d factor concentrates may be prohibitive.
Localization (expense) of d factor
1) Confidence 0.73 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835555 Disease Relevance 0.47 Pain Relevance 0
Measurement of IL-6, IL-11 and LIF levels
Localization (Measurement) of LIF
2) Confidence 0.56 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 0.66 Pain Relevance 0.38
mediate the secretion of LIF through chondrocytes, and LIF contributes to cartilaginous destruction by inducing the absorption of proteoglycan in patients with chronic arthritis.24,25
Localization (secretion) of LIF in chondrocytes associated with arthritis
3) Confidence 0.52 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.19 Pain Relevance 0.80
LPS and CpG-DNA) stimulate innate immune cells to release
           a wide array of pro-inflammatory mediators, including nitric oxide (Ref. 16), TNF (Ref. 17), IL-1 (Ref. 18), leukaemia
           inhibitory factor (LIF) (Ref. 19), interferon
           (IFN)-? 
Localization (release) of LIF in immune cells associated with leukemia and inflammatory mediators
4) Confidence 0.26 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.63 Pain Relevance 0.40

General Comments

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