INT253752

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Apex1) mitochondrion (Apex1) lyase activity (Apex1)
aging (Apex1) endoplasmic reticulum (Apex1) intracellular (Apex1)
Anatomy Link Frequency
monocyte 3
macrophage 1
Apex1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 72 74.12 Quite High
cytokine 46 62.76 Quite High
Nicotine 2 9.20 Low Low
agonist 2 8.84 Low Low
Inflammatory response 54 5.00 Very Low Very Low Very Low
Inflammatory mediators 30 5.00 Very Low Very Low Very Low
vagus nerve 12 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 198 94.08 High High
Gynecological Disease 2 91.96 High High
Disease 28 87.92 High High
INFLAMMATION 166 74.12 Quite High
Infection 36 5.00 Very Low Very Low Very Low
Injury 28 5.00 Very Low Very Low Very Low
Apoptosis 22 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Necrosis 8 5.00 Very Low Very Low Very Low
Adult Respiratory Distress Syndrome 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its aqueous extract
           dose-dependently inhibited LPS-induced HMGB1 release in macrophage and monocyte
           cultures, partly by interfering with HMGB1 cytoplasmic translocation (Ref. 134). 
Negative_regulation (interfering) of Localization (translocation) of Ref in monocyte
1) Confidence 0.08 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.63 Pain Relevance 0.10
Its aqueous extract
           dose-dependently inhibited LPS-induced HMGB1 release in macrophage and monocyte
           cultures, partly by interfering with HMGB1 cytoplasmic translocation (Ref. 134). 
Negative_regulation (interfering) of in macrophage Localization (translocation) of Ref in monocyte
2) Confidence 0.03 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.63 Pain Relevance 0.10

General Comments

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