INT253755

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 6.23
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) extracellular region (Hmgb1) cell morphogenesis (Hmgb1)
nucleolus (Hmgb1) chromosome (Hmgb1) nucleus (Hmgb1)
Anatomy Link Frequency
lung 1
microglia 1
Hmgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 246 100.00 Very High Very High Very High
cytokine 220 100.00 Very High Very High Very High
Inflammatory response 160 98.88 Very High Very High Very High
Hippocampus 26 96.36 Very High Very High Very High
long-term potentiation 2 90.40 High High
Inflammatory marker 5 90.28 High High
rheumatoid arthritis 15 84.64 Quite High
Etanercept 5 74.92 Quite High
Infliximab 5 71.84 Quite High
Inflammatory mediators 81 71.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 513 100.00 Very High Very High Very High
Sepsis 511 100.00 Very High Very High Very High
Urological Neuroanatomy 5 99.84 Very High Very High Very High
Cognitive Disorder 74 99.04 Very High Very High Very High
Infection 98 96.88 Very High Very High Very High
Burns 63 95.64 Very High Very High Very High
Disease 77 93.96 High High
Injury 101 92.32 High High
Death 10 91.44 High High
Keloid Scars 2 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, chemical modifications may similarly affect the biological
       activities of HMGB1. 
Spec (may) Regulation (affect) of HMGB1
1) Confidence 0.55 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.18 Pain Relevance 0.04
Targeting IL-1 ameliorates the cognitive abnormality by reducing microglia but does not affect HMGB1
Neg (not) Regulation (affect) of HMGB1 in microglia associated with cognitive disorder
2) Confidence 0.39 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.87 Pain Relevance 0.29
In contrast to the early anti-inflammatory transcriptomic pattern observed during lung regeneration in this study, another recent study describes up-regulation of select inflammatory cytokines (Hmgb1 and INF-y) during post-pneumonectomy lung regeneration, although most cytokines studied were unaffected by the procedure [38].


Regulation (regulation) of Hmgb1 in lung associated with inflammation and cytokine
3) Confidence 0.30 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.87 Pain Relevance 0.38
Because Cys106 is located
       within the 18-amino-acid cytokine domain of HMGB1 B box, it will be important to investigate
       whether oxidisation similarly affects biological activities of HMGB1 in future studies.
Spec (whether) Regulation (affects) of HMGB1 associated with cytokine
4) Confidence 0.24 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.21 Pain Relevance 0.05
The HMG boxes enable HMGB1 to bind chromosomal DNA and fulfil its nuclear
         functions, including determination of nucleosomal structure and stability, and regulation
         of gene expression (Ref. 49).


Regulation (regulation) of HMGB1
5) Confidence 0.24 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.33 Pain Relevance 0.06
Here, we briefly
       review the prevailing theories of sepsis as an uncontrolled systemic inflammatory response,
       and discuss potential therapeutic agents that target clinically more feasible, late-acting
       mediators of experimental sepsis, such as HMGB1.
Regulation (target) of HMGB1 associated with inflammatory response and sepsis
6) Confidence 0.24 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.57 Pain Relevance 0.18
Although HMGB1 appears to be a feasible therapeutic target for
       experimental sepsis (Refs 96, 146, 147), its levels in
       unfractionated crude serum of septic patients did not correlated well with disease severity
       (Refs 148, 149). 
Regulation (target) of HMGB1 associated with disease and sepsis
7) Confidence 0.24 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.23 Pain Relevance 0.42
Interestingly, IL-1Ra treatment had no effects on HMGB-1 levels, which maintained a similar pattern to that seen after LPS injection in the absence of IL-1Ra (Figure 2c).
Neg (no) Regulation (effects) of HMGB-1
8) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.29 Pain Relevance 0.30
A change in circulating levels of the HMGB-1 was also not evident in the current study.
Regulation (change) of HMGB-1
9) Confidence 0.16 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 0.68 Pain Relevance 0.08

General Comments

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