INT253756

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 7.47
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Apex1) mitochondrion (Apex1) lyase activity (Apex1)
aging (Apex1) endoplasmic reticulum (Apex1) intracellular (Apex1)
Anatomy Link Frequency
monocytes 5
macrophage 1
immune cells 1
body 1
Apex1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 324 100.00 Very High Very High Very High
cytokine 207 100.00 Very High Very High Very High
chemokine 45 100.00 Very High Very High Very High
Inflammatory mediators 135 97.68 Very High Very High Very High
Inflammatory response 243 95.56 Very High Very High Very High
Nicotine 9 68.64 Quite High
agonist 9 68.28 Quite High
vagus nerve 54 63.04 Quite High
Inflammatory stimuli 18 59.08 Quite High
Neurotransmitter 18 34.56 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 747 100.00 Very High Very High Very High
Cancer 45 100.00 Very High Very High Very High
Infection 162 97.44 Very High Very High Very High
Sepsis 891 96.96 Very High Very High Very High
Shock 18 96.48 Very High Very High Very High
Dengue 9 91.20 High High
Injury 126 91.04 High High
Anaemia 9 90.48 High High
Lifespan 9 81.04 Quite High
Leukemia 9 70.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Engagement of various TLRs by specific PAMPs leads to production and release of cytokines
         (such as TNF and the interleukins IL- 1 and IL-6) and chemokines (such as IL-8, and the
         ‘macrophage inflammatory proteins’ CCL3 and CCL4) (Ref. 12). 
Gene_expression (production) of Ref in macrophage associated with chemokine, inflammation and cytokine
1) Confidence 0.14 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.07 Pain Relevance 0.49
Accumulating evidence indicates that HMGB1 can stimulating migration of neurites (Ref.
             61), smooth muscle cells (Ref. 62), tumour cells (Ref. 63), mesoangioblast stem cells (Refs 64, 65), monocytes (Ref.
             66), dendritic cells (Refs 67, 68)
           and neutrophils (Ref. 69) (Fig. 2). 
Gene_expression (migration) of Ref in monocytes associated with cancer
2) Confidence 0.14 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.68 Pain Relevance 0.11
Neutrophils and monocytes continuously patrol the body to search for invading pathogens,
         and infiltrate into infected/injured tissues upon detecting microbial products (Ref. 3). 
Gene_expression (products) of Ref in body
3) Confidence 0.14 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.08 Pain Relevance 0.08
Accumulating evidence indicates that HMGB1 can stimulating migration of neurites (Ref.
             61), smooth muscle cells (Ref. 62), tumour cells (Ref. 63), mesoangioblast stem cells (Refs 64, 65), monocytes (Ref.
             66), dendritic cells (Refs 67, 68)
           and neutrophils (Ref. 69) (Fig. 2). 
Gene_expression (migration) of Ref in monocytes associated with cancer
4) Confidence 0.14 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.70 Pain Relevance 0.11
Accumulating evidence indicates that HMGB1 can stimulating migration of neurites (Ref.
             61), smooth muscle cells (Ref. 62), tumour cells (Ref. 63), mesoangioblast stem cells (Refs 64, 65), monocytes (Ref.
             66), dendritic cells (Refs 67, 68)
           and neutrophils (Ref. 69) (Fig. 2). 
Gene_expression (migration) of Ref in monocytes associated with cancer
5) Confidence 0.14 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.71 Pain Relevance 0.12
Microbial products also stimulate innate immune cells to produce anti-inflammatory
           mediators, such as prostaglandin E2 (PGE2) (Ref. 25), IL-10 (Refs 26, 27) and transforming growth
           factor (TGF)-? 
Gene_expression (produce) of Ref in immune cells associated with inflammation
6) Confidence 0.12 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.46 Pain Relevance 0.53
Accumulating evidence indicates that HMGB1 can stimulating migration of neurites (Ref.
             61), smooth muscle cells (Ref. 62), tumour cells (Ref. 63), mesoangioblast stem cells (Refs 64, 65), monocytes (Ref.
             66), dendritic cells (Refs 67, 68)
           and neutrophils (Ref. 69) (Fig. 2). 
Gene_expression (migration) of Ref in monocytes associated with cancer
7) Confidence 0.12 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.69 Pain Relevance 0.11
Accumulating evidence indicates that HMGB1 can stimulating migration of neurites (Ref.
             61), smooth muscle cells (Ref. 62), tumour cells (Ref. 63), mesoangioblast stem cells (Refs 64, 65), monocytes (Ref.
             66), dendritic cells (Refs 67, 68)
           and neutrophils (Ref. 69) (Fig. 2). 
Gene_expression (migration) of Ref in monocytes associated with cancer
8) Confidence 0.12 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.72 Pain Relevance 0.12
Indeed, administration of
         stearoyl LPC significantly attenuated circulating HMGB1 levels (Ref. 47), indicating that stearoyl LPC protects against experimental
         sepsis partly by facilitating elimination of invading pathogens and partly by attenuating
         systemic HMGB1 accumulation (Ref. 130).


Gene_expression (levels) of Ref associated with sepsis
9) Confidence 0.12 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.36 Pain Relevance 0.16

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