INT253759

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.53
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Hmgb1, Apex1) nucleus (Hmgb1, Apex1) cytoplasm (Hmgb1, Apex1)
nucleolus (Hmgb1, Apex1) nucleoplasm (Apex1) mitochondrion (Apex1)
Anatomy Link Frequency
lung 3
Hmgb1 (Mus musculus)
Apex1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 108 96.64 Very High Very High Very High
antagonist 6 89.08 High High
cytokine 69 79.20 Quite High
Inflammatory mediators 45 52.56 Quite High
Inflammatory response 81 5.00 Very Low Very Low Very Low
vagus nerve 18 5.00 Very Low Very Low Very Low
cINOD 15 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 12 100.00 Very High Very High Very High
Pancreatitis 3 100.00 Very High Very High Very High
Hemorrhagic Shock 3 100.00 Very High Very High Very High
Injury 42 98.96 Very High Very High Very High
INFLAMMATION 249 96.64 Very High Very High Very High
Disease 42 96.12 Very High Very High Very High
Myocardial Infarction 3 92.44 High High
Cv Unclassified Under Development 3 73.08 Quite High
Sepsis 297 70.56 Quite High
Fever 9 53.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, HMGB1-specific neutralising antibodies have been proven protective against
           ventilator-induced acute lung injury (Ref. 104), severe acute pancreatitis (Ref. 105), and haemorrhagic shock (Ref. 106), supporting a pathogenic role for extracellular HMGB1 in various
           inflammatory diseases. 
HMGB1 Positive_regulation (induced) of Ref in lung associated with inflammation, pancreatitis, adult respiratory distress syndrome, disease and hemorrhagic shock
1) Confidence 0.09 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.47 Pain Relevance 0.22
In addition, HMGB1-specific neutralising antibodies have been proven protective against
           ventilator-induced acute lung injury (Ref. 104), severe acute pancreatitis (Ref. 105), and haemorrhagic shock (Ref. 106), supporting a pathogenic role for extracellular HMGB1 in various
           inflammatory diseases. 
HMGB1 Positive_regulation (induced) of Ref in lung associated with inflammation, pancreatitis, adult respiratory distress syndrome, disease and hemorrhagic shock
2) Confidence 0.09 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.59 Pain Relevance 0.25
In addition, HMGB1-specific neutralising antibodies have been proven protective against
           ventilator-induced acute lung injury (Ref. 104), severe acute pancreatitis (Ref. 105), and haemorrhagic shock (Ref. 106), supporting a pathogenic role for extracellular HMGB1 in various
           inflammatory diseases. 
HMGB1 Positive_regulation (induced) of Ref in lung associated with inflammation, pancreatitis, adult respiratory distress syndrome, disease and hemorrhagic shock
3) Confidence 0.09 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.48 Pain Relevance 0.22

General Comments

This test has worked.

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